Skip to main content

Advertisement

SpringerLink
Log in

Ectopic pituitary adenoma with empty sella in the setting of MEN-1 syndrome: detection with 68Ga-DOTANOC PET/CT

  • Case report
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Patients with multiple endocrine neoplasia type-1 syndromes are known to have neuroendocrine tumors (NETs) involving the pituitary and gastroenteropancreatic region, in addition to the presence of parathyroid abnormalities. In rare instances adenomas in the ectopic pituitary gland have been reported. As pituitary gland and pituitary adenomas are known to express SSTRs, somatostatin receptor scintigraphy can be used for imaging. Somatostatin receptor-based PET/CT imaging using 68Ga-DOTANOC has become a popular noninvasive imaging modality for evaluation of patients with NETs. The application of 68Ga-DOTANOC PET/CT can be extended to multiple endocrine neoplasia type 1 patients, as is evident from this case study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Gibril F, Schumann M, Pace A, Jensen RT. Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: a prospective study of 107 cases and comparison with 1009 cases from the literature. Medicine (Baltimore). 2004;83:43–83.

    Article  Google Scholar 

  2. Yang BT, Chong VF, Wang ZC, Xian JF, Chen QH. Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings. Br J Radiol. 2010;83:218–24.

    Article  PubMed  CAS  Google Scholar 

  3. Kusano Y, Horiuchi T, Oya F, Miyaoka Y, Oguchi K, Takemae T, et al. Ectopic pituitary adenoma associated with an empty sella: a case report and review of the literature. J Neuroimaging. 2011;XX:1–2. doi:10.1111/j.1552-6569.2011.00620.

    Google Scholar 

  4. Muhr C, Ljunhhall S, Akerstrom G, Palmer M, Bergstrom K, Enoksson P, et al. Screening for multiple endocrine neoplasia syndrome (type 1) in patients with primary hyperparathyroidism. Clin Endocrinol. 1984;20:153–62.

    Article  CAS  Google Scholar 

  5. DeMonte F, Ginsberg LE, Clayman GL. Primary malignant tumors of the sphenoidal sinus. Neurosurgery. 2000;46:1084–91.

    Article  PubMed  CAS  Google Scholar 

  6. O’Brien T, O’Riordan DS, Gharib H, Scheithauer BW, Ebersold MJ, van Heerden JA. Results of treatment of pituitary disease in multiple endocrine neoplasia, type 1. Neurosurgery. 1996;39:273–9.

    Article  PubMed  Google Scholar 

  7. Garber JE, Kenneth O. Hereditary cancer predisposition syndromes. Clin Oncol. 2005;23:276–92.

    Article  Google Scholar 

  8. Ambrosini V, Campana D, Bodei L, Nanni C, Castellucci P, Allegri V, et al. 68Ga-DOTANOC PET/CT clinical impact in patients with neuroendocrine tumours. J Nucl Med. 2010;51:669–73.

    Article  PubMed  Google Scholar 

  9. Arman R, Habib Z. PET versus SPECT: strengths, limitations and challenges. Nucl Med Commun. 2008;29:193–220.

    Article  Google Scholar 

  10. Hofland LJ, Lamberts SW. Somatostatin receptors in pituitary function, diagnosis and therapy. Front Horm Res. 2004;32:235–52.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that there is no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (East), AIIMS Campus, New Delhi, 110029, India

    Niraj Naswa, Punit Sharma, Sellam Karunanithi, Chandrasekhar Bal & Rakesh Kumar

  2. Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

    Chandan Jyoti Das

Authors
  1. Niraj Naswa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chandan Jyoti Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Punit Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sellam Karunanithi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chandrasekhar Bal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rakesh Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rakesh Kumar.

About this article

Cite this article

Naswa, N., Das, C.J., Sharma, P. et al. Ectopic pituitary adenoma with empty sella in the setting of MEN-1 syndrome: detection with 68Ga-DOTANOC PET/CT. Jpn J Radiol 30, 783–786 (2012). https://doi.org/10.1007/s11604-012-0117-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-012-0117-0

Keywords

Search

Navigation