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Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk

  • Epidemiology
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Abstract

Three known non-synonymous polymorphisms (Ala394Thr, Ser471Leu and Pro690Ala) in the largest circadian gene, Neuronal PAS domain protein 2 (NPAS2), were genotyped in a breast cancer case-control study conducted in Connecticut, USA (431 cases and 476 controls). We found that women with the heterozygous Ala394Thr genotype were significantly associated with breast cancer risk compared to those with the common homozygous Ala394Ala (OR = 0.61, 0.46–0.81, P = 0.001). This is the first evidence demonstrating a role of the circadian gene NPAS2 in human breast cancer, suggesting that genetic variations in circadian genes might be a novel panel of biomarkers for breast cancer risk.

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Acknowledgments

This study was supported by funds from Yale University. The work was also supported by the NIH grants CA62986, CA110937, CA108369, ES11659 and CA122676.

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Authors and Affiliations

  1. Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH Room 702, New Haven, CT, 06520, USA

    Yong Zhu, Derek Leaderer, Aaron Hoffman, Theodore Holford, Yawei Zhang, Heather N. Brown & Tongzhang Zheng

  2. University of Connecticut Health Center, Farmington, CT, 06030-6325, USA

    Richard G. Stevens

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  1. Yong Zhu
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  2. Richard G. Stevens
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  3. Derek Leaderer
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  4. Aaron Hoffman
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  5. Theodore Holford
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  6. Yawei Zhang
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  7. Heather N. Brown
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  8. Tongzhang Zheng
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Correspondence to Yong Zhu.

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Zhu, Y., Stevens, R.G., Leaderer, D. et al. Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk . Breast Cancer Res Treat 107, 421–425 (2008). https://doi.org/10.1007/s10549-007-9565-0

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  • DOI: https://doi.org/10.1007/s10549-007-9565-0

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