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Biochemical assessment of bone turnover and bone fragility in men

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Abstract

Summary

Osteoporosis in men is less studied than in women. Few data concern biochemical bone turnover markers (BTM) in men and their potential use.

Methodology

We evaluated papers concerning BTM in men cited on Medline. Selection of studies were based on the number of subjects, age range, group homogeneity, follow-up duration, number of BTM.

Results

BTM levels are high in young men, then decrease with age.In elderly men, bone resorption increases with age more than bone formation. Variability of individual values is high and their significance is unclear. In elderly men, BTM levels correlate negatively with bone mineral density suggesting that accelerated bone turnover underlies age-related bone loss. Data on the prediction of accelerated bone loss and fractures by BTM in men are scant. Testosterone treatment induces a decrease in bone resorption followed by a decrease in bone formation. Bisphosphonates and calcitonin decrease BTM levels in osteoporotic men. Parathyroid hormone 1–34 and growth hormone induce a rapid increase in bone turnover followed by a progressive slowdown.

Conclusions

Few studies concern BTM in men. Currently available data are not sufficient to suggest guidelines for the practical use of BTM in the clinical management of the osteoporosis in elderly men.

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Abbreviations

BTM:

bone turnover marker

aBMD:

areal bone mineral density

OC:

osteocalcin

BAP:

bone alkaline phosphatase

PINP:

procollagen type I N propeptide

PICP:

procollagen type I C propeptide

DPD:

deoxypyridinoline

Gal-Hyl:

galactosyl hydroxylysine

PYD:

pyridinoline

Hyl:

hydroxylysine

Hyp:

hydroxyproline

CTX-I:

C-terminal crosslinking telopeptide of type I collagen

NTX-I:

N-terminal crosslinking telopeptide of type I collagen

CTX-MMP (ICTP):

C-terminal crosslinking telopeptide of type I collagen generated by metalloproteinases

TRACP5b:

tartrate-resistant acid phosphatase type 5b

BioT:

bioavailable testosterone

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Authors and Affiliations

  1. INSERM Research Unit 831, University of Lyon, Lyon, France

    P. Szulc & P. D. Delmas

  2. University of Ghent, Ghent, Belgium

    J. M. Kaufman

  3. INSERM 831 Research Unit, Hôpital Edouard Herriot, Pavillon F, Lyon, France

    P. Szulc

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  1. P. Szulc
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Correspondence to P. Szulc.

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This manuscript was prepared as a part of the NEMO study (Thematic Network on the Osteoporosis in Men).

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Szulc, P., Kaufman, J.M. & Delmas, P.D. Biochemical assessment of bone turnover and bone fragility in men. Osteoporos Int 18, 1451–1461 (2007). https://doi.org/10.1007/s00198-007-0407-z

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