Summary
If one investigates a process that has several causes but assumes that it has only one cause, one risks ruling out important causal factors. Three mechanisms account for this mistake: either the significance of the single cause under test is masked by noise contributed by the unsuspected and uncontrolled factors, or the process appears only when two or more causes interact, or the process appears when there are present any of a number of sufficient causes which are not mutally exclusive. In ecology and evolutionary biology, experiments usually test single factor hypotheses, and many scientists apparently believe that hypotheses incorporating several factors are so much more difficult to test that to do so would not be practical. We discuss several areas in ecology and evolutionary biology in which the presupposition of simple causation has apparently impeded progress. We also examine a more mature field, the study of atherosclerosis, in which single factor studies did significantly delay progress towards understanding what now appears to be a multifactor process. The problem has three solutions: either factorial experiments, dynamic models that make quantitative predictions, response-surface methods, or all three. In choosing a definition for ‘cause’, we make a presupposition that profoundly influences subsequent observations and experimental designs. Alternative definitions of causation should be considered as contributing to potential cures for research problems.
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References
Andersson, M. & L. Hansson (1974). Population regulation in small rodents — some hypotheses (original title in Swedish). - Fauna och Flora,69, p. 113–126.
Ashby, W.R. (1956). An introduction to cybernetics. - London, Chapman & Hall.
Astrup, P. & K. Kjeldsen (1974). Carbon monoxide, smoking, and atherosclerosis. - Med. Clin. N. Amer.48, p. 325–350.
Beaumont, J.L. & U. Beaumont (1978). Immunological aspects of atherosclerosis. - Atherosclerosis Rev.3, p. 133–146.
Benditt, E.P. (1978). The monoclonal theory of atherogenesis. - Atherosclerosis Rev.3, p. 77–86.
Benditt, E.P. & J.M. Benditt (1973). Evidence for a monoclonal origin of human atherosclerotic plaques. -Proc. nat. Acad. Sci. USA70, p. 1753–1756.
Box, G.E.P., W.G. Hunter & J.S. Hunter (1978). Statistics for experimenters. - New York, J. Wiley & Sons.
Chitty, D. (1960). Population processes in the vole and their relevance to general theory. - Can. J. Zool.38, p. 99–113.
Chitty, D. (1967). The natural selection of self-regulatory behavior in animal populations. - Proc. ecol. Soc. Aust.2, p. 51–78.
Cochran, W.G. & G.M. Cox (1957). Experimental designs. 2nd Ed. - New York, J. Wiley & Sons.
Cohen, M.R. & E. Nagel (1934). An introduction to logic and scientific method. - London, Routledge.
Critchley, M., ed. (1978) Butterworths medical dictionary. - London, Butterworths.
Duguid, J.B. (1949). Pathogenesis of atherosclerosis. - Lancet2, p. 925–927.
French, J.E. (1966). Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to the endothelium. - Int. Rev. exp. Pathol.5, p. 253–353.
Gilbert, N., A.P. Gutierrez, B.D. Fraser & R.E. Jones (1976). Ecological relationships. -Reading, W.H. Freeman.
Gotto, A.M., Jr. (1979). Status report: plasma lipids, lipoproteins, and coronary heart disease. - Atherosclerosis Rev.4, p. 17–28.
Gries, F.A., T. Koschinsky & P. Buchtold (1979). Obesity, diabetes, and hyperlipoproteinemia. -Atherosclerosis Rev.4, p. 71–96.
Gresham, G.A. (1976). Atherosclerosis: its causes and potential reversibility. - Triangle15, p. 39–43.
Kannel, W.B. & T. Gordon, eds. (1971). The Framingham Study. An epidemiological investigation of cardiovascular disease. Section 27. - Washington, U.S. Govt. Printing Office.
Keith, L.B. (1974). Some features of population dynamics in mammals. - Proc. int. Congr. Game Biol.11, p. 17–58.
Krebs, C.J. (1978a). A review of the Chitty Hypothesis of population regulation. - Can. J. Zool.56, p. 2463–2480.
Krebs, C.J. (1978b). Dispersal, spacing behavior and genetics in relation to population fluctuations in the voleMicrotus townsendii. - Forsch. Zool.25, p. 61–77.
Krebs, C.J. & J.H. Myers (1974). Population cycles in small mammals. - Adv. ecol. Res.8, p. 267–399.
Lewontin, R.C. (1974a). The analysis of variance and the analysis of causes. - Am. J. hum. Genet.26, p. 400–411.
Lewontin, R.C. (1974b). The genetic basis of evolutionary change. - New York, Columbia University Press.
Lidicker, W.Z., Jr. (1978). Regulation of numbers in small mammal populations —historical reflections and a synthesis. — In: D.P. Snyder, ed., Populations of small mammals under natural conditions.
Mackie, J.L. (1965). Causes and conditions. - Amer. phil. Quart.2, p. 245–255, p. 261-264.
McGill, H.C., Jr. (1977). Atherosclerosis: problems in pathogenesis. - Atherosclerosis Rev.2, p. 27–65.
McGill, H.C., Jr. & M.P. Stern (1979). Sex and atherosclerosis. - Atherosclerosis Rev.4, p. 157–242.
Mustard, J.F. & M.A. Packingham (1975). The role of blood and platelets in atherosclerosis. - Thromb. Diath. Haemorrh.33, p. 444–456.
Nagel, E. (1961). The structure of science. - New York, Harcourt, Brace, & World, Inc.
Pearson, O.P. (1966). The prey of carnivores during one cycle of mouse abundance. - J. anim. Ecol.35, p. 217–233.
Pitelka, F.A. (1973). Cyclic pattern in lemming populations near Barrow, Alaska. — In: M.E. Britton, ed., Alaskan arctic tundra. — AINA Techn. Paper25, p. 199–215.
Popper, K.R. (1959). The logic of scientific discovery. - London, Hutchinson.
Ross, R. & J.A. Glomset (1976). The pathogenesis of atherosclerosis. - New Eng. J. Med.295, p. 369–377.
Simon, H.A. (1962). The architecture of complexity. - In: H.A. Simon (1969). The sciences of the artifical.- Cambridge, MIT Press.
Southwood, T.R.E. (1980). Ecology — a mixture of pattern and probabilism. - Synthese43, p. 111–122.
Stearns, S.C. (1976). Life-history tactics: a review of the ideas. - Quart. Rev. Biol.51, p. 3–47.
Steams, S.C. & R.E. Crandall (1981, in press), Quantitative predictions of delayed maturity. — Evolution35.
Stebbing, L.S. (1931). A modern introduction to logic. - London, Methuen & Co.
Strong, D.R., Jr. (1980). Null hypotheses in ecology. - Synthese43, p. 271–285.
Taitt, M. (1978). Population dynamics ofPeromyscus maniculatus auterus andMicrotus townsendii with supplementary food. -Ph.D. thesis, Dept. of Zoology, Univ. of British Columbia.
Texon, M. (1974). Atherosclerosis: its hemodynamic basis and implications. - Med. Clin. N. Amer.58, p. 257–268.
Wilson, E.O. (1975) Sociobiology: The new synthesis. - Cambridge, Belknap Press.
Wimsatt, W.C. (1974). Complexity and organization. - In: K.F. Schaffner & R.S. Cohen, eds., Boston Studies in the Philosophy of Science,35, p. 67–86. - Dordrecht (Holland), Reidel.
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Hilborn, R., Stearns, S.C. On inference in ecology and evolutionary biology: the problem of multiple causes. Acta Biotheor 31, 145–164 (1982). https://doi.org/10.1007/BF01857238
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DOI: https://doi.org/10.1007/BF01857238