Summary
Evidence from results of autoradiographic studies in mice indicates that nuclei of Sertoli cells and of epithelial cells in the ductuli efferentes contain receptors for 1,25(OH)2 vitamin D3.
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Clark SA, Stumpf WE, Sar M, DeLuca HF, Tanaka Y (1980) Target cells for 1,25 dihydroxyvitamin D3 in the pancreas. Cell Tissue Res 209:515–520
Clark SA, Stumpf WE, Sar M (1981) Effect of 1,25 dihydroxyvitamin D3 on insulin secretion. Diabetes 30:382–386
Clark SA, Stumpf WE, Bishop CW, DeLuca HF, Park DH, Joh TH (1985) Identification and developmental appearance of calcitriol (1,25-vitamin D3) target cells and cells with vitamin Dedependent calcium-binding protein in the adrenal. Anat Rec 211:42A
Clark SA, Stumpf WE, Bishop CW, DeLuca HF, Park DH, Joh TH (1986) The adrenal: a new target organ of the calciotropic hormone 125dihydroxyvitamin D3. Cell Tissue Res 243:299–302
Kream BE, Yamada S, Schnoes HK, DeLuca HF (1977) Specific cytosol-binding protein for 1,25-dihydroxyvitamin D3 in rat intestine. J Biol Chem 252:4501–4505
Levy FO, Eikvar L, Jute NHPM, Cervenka J, Yoganathan T, Hansson V (1985) Appearance of the rat testicular receptor for calcitriol (1,25-dihydroxyvitamin B3) during development. J Steroid Biochem 23:51–56
Levy FO, Eikvar L, Jutte NHPM, Froysa A, Tvermyr SM, Hansson V (1985) Properties and compartmentalization of the testicular receptor for 1,25-dihydroxyvitamin D3. J Steroid Biochem 22:453–460
Merke J, Kreussler W, Bier B, Ritz E (1983) Demonstration and characterisation of a testicular receptor for 1,25-dihydroxycholecalciferol in the rat. J Biochem 130:303–308
Sar M, Stumpf WE, DeLuca HF (1980) Thyrotropes in the pituitary are target cells for 1,25 (OH)2 vitamin D3. Cell Tissue Res 209:161–166
Sar M, Miller WL, Stumpf WE (1981) Effects of 1,25 (OH)2 vitamin D3 on thyrotropin secretion in vitamin D deficient male rats. Physiologist 24:70
Stumpf WE, Sar M (1975) Autoradiographic techniques for localizing steroid hormones. In: OMalley BW, Hardman JG (eds) Methods in Enzymology, vol. 36, Hormone action, Part A. Steroid Hormones. Academic Press, New York, pp 135–156
Stumpf WE, Baerwaldt C, Sar M (1971) Autoradiographic cellular and subcellular localization of sexual steroids. In: Hubinont PO, Leroy F, Galand P (eds) Basic Actions of Sex Steroids on Target Organs. S Karger, Basel, pp 3–20
Stumpf WE, Sar M, Reid FA, Tanaka Y, DeLuca HF (1979) Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary and parathyroid. Science 206:1188–1190
Stumpf WE, Sar M, Narbaitz R, Reid FA, DeLuca HF, Tanaka Y (1980) Cellular and subcellular localization of 1,25(OH)2 vitamin D3 in rat kidney. Comparison with that of parathyroid hormone and estradiol. Proc Natl Acad Sci USA 77:1149–1153
Stumpf WE, Sar M, Clark SA, Lieth E, DeLuca HF (1980) Target neurons for 1,25 (OH)2 vitamin D3 in brain and spinal cord. Neuroendocrinol Lett 2:297–301
Stumpf WE, Sar M, DeLuca HF (1981) Sites of action of 1,25 (OH)2 vitamin D3 identified by thaw-mount autoradiography. In: Cohn DV, Talmage RV, Matthews JL (eds) Hormonal control of calcium metabolism. Excerpta Medica, Amsterdam, pp 222–229
Stumpf WE, Sar M, Clark SA, DeLuca HF (1982) Brain target sites for 1,25-dihydroxyvitamin D3. Science 215:1403–1405
Stumpf WE, Clark SA, Sar M, DeLuca HF (1984) Topographical and developmental studies on 1,25 (OH)2 vitamin D3 target sites in skin. Cell Tissue Res 238:489–496
Walters MR, Hunziker W, Norman AW (1980) Unoccupied 1,25-dihydroxyvitamin D3 receptors (1980) J Biol Chem 255:6799–6805
Walters MR, Cuneo DL, Jamison AP (1983) Possible significance of new target tissues for 1,25-dihydroxyvitamin D3. J Steroid Biochem 19:913–920
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Stumpf, W.E., Sar, M., Chen, K. et al. Sertoli cells in the testis and epithelium of the ductuli efferentes are targets for 3H 1,25 (OH)2 vitamin D3 . Cell Tissue Res. 247, 453–455 (1987). https://doi.org/10.1007/BF00218327
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DOI: https://doi.org/10.1007/BF00218327