Affiliations: Argus Biosciences, Belmont, CA, USA | Centre for Bioinformatics, University of Kerala,
Trivandrum, India | Department of Zoology, University of Kerala,
Trivandrum, India
Note: [] Corresponding author: Centre for Bioinformatics, University of
Kerala, Trivandrum 695581, India. E-mail: [email protected]
Abstract: An online tool named GEN-SNiP that identifies variations in a set of
test DNA sequences with respect to a standard reference sequence is developed
and deployed successfully. The tool generates a list of substitutions,
insertions and deletions for each test sequences, determined by the reference
sequence. In the key batch mode feature, the tool allows multiple sequences to
be compared and contrasted even when small insertions and deletions are
present, with results sent to the user via email. Other distinguishing features
of the tool are grouping of continuous deletions or insertions in the test
sequence into a single entity for better output handling, displaying of the
alignment of test and reference sequence and the input sequence. The tool has
been reported as unique in recent literature.
Keywords: Single nucleotide polymorphism (SNP), mitochondrial DNA (mtDNA), sequence analysis, genome, revised Cambridge reference sequence
