A Synthesis of Substituted 1,3,4-Oxadiazole, Pyrazole Deravatives and It’s Biological Activities
Alphonsus D’souza *
Department of Chemistry, St. Philomena’s College (Autonomous) Mysuru- 560001,Karnataka, India.
Prashant Nayak
Department of pharmaceutics, NGSM Institute of pharmaceutical sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore, 575018, Karnataka, India.
Prasanna Shama Khandige
Department of pharmacology, NGSM Institute of pharmaceutical sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore, 575018, Karnataka, India.
Pankaj Kumar
Department of pharmaceutical chemistry, NGSM Institute of pharmaceutical sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore, 575018 Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: Nicotine Substituted 1,3,4 Oxadiazole and pyrazole moieties were integrated by utilizing hydrazide as halfway .Oxadiazole were acquired by two techniques one is by utilizing PoCl3 within the sight of fragrant corrosive ,other is by utilizing carbon disulphide in the presence ofpotassium hydroxide as an impetus .Pyrazoles were likewise gotten by ehtylacetoacetate we acquired unrefined item and again it was recrystallized by utilizing alcohol.All incorporated mixtures were evaluated for Antibacterial activity and enaminones showed promising action against standard medication ciprofloxacin.
Methods: TLC on silica gel G was used to check for homogeneity of the title compound. H NMR, Mass, and IR Spectra were used to characterise these compounds, and their antibacterial activity was tested.
Results: All of these compounds, including nicotine substituted ester, hydrazide, 1,3,4 Oxadiazole, and pyrazole, showed antibacterial activity. The maximum activity of enaminones was comparable to that of the standard drug ciprofloxacin (5mcg). Compound1 showed potent antimicrobial activity
Conclusion: In the zone of inhibition studies, all six samples at MIC concentrations showed reasonable antimicrobial activity Compound1 showed very good antimicrobial activity
Keywords: Enaminones, nicotinic hydrazide, nictonic substituted oxadiazole, nicotin substituted pyrazole