Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Evaluation of Acoustic, Thermal, and Morphological Properties in the Egg White Phantom

  • Kim, Mi-Seon (Department of Biomedical Engineering, Inje University) ;
  • Kim, Ju-Young (Department of Biomedical Engineering, Inje University) ;
  • Moon, Dong-Jun (Department of Biomedical Engineering, Inje University) ;
  • Noh, Si-Cheol (Department of Radiological Science, International University of Korea) ;
  • Choi, Heung-Ho (Department of Biomedical Engineering, Inje University)
  • Received : 2014.09.11
  • Accepted : 2014.12.30
  • Published : 2015.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

The egg white phantom is a thermal lesion visualization phantom able to illustrate a thermal lesion. It is often used to evaluate the performance of HIFU and is less expensive than the BSA phantom. This study determined the optimal phantom composition for evaluated therapeutic ultrasound machines by varying the egg white concentration in the egg white phantom and demonstrated its utility as a therapeutic ultrasound phantom. The egg white phantom at varying egg white concentrations (10-40% in 10% intervals) was fabricated, and its thermal properties and acoustic properties were assessed. In addition, the size and shape of the formed lesion were compared between the egg white phantom and bovine liver tissue according to the electrical power. The results showed that 30% egg white phantom was optimal for the performance evaluation due to its thermal and acoustic properties. The generated thermal lesions formed sequentially as a cigar, ellipse, tadpole, and cone shapes according to the electrical power; a similar tendency was observed in the liver tissue. Hence, we conclude that the egg white phantom will prove useful in quantitatively evaluating the thermal effects of therapeutic ultrasound.

Keywords

References

  1. J.S. Yang, Radiation effect on characteristics of radiationcopolymerized methacryloyl-L-alanine methyl ester-co-2-hydroxypropyl methacrylate hydrogel and biochemical properties of ovomucoid, Daejeon, Korea: Korea Advanced Institute of Science and Technology, 1996, pp. 22-24.
  2. A.F. Prokop, S. Vaezy, M.L. Noble, P.J. Kaczkowski, R.W. Martin, and L.A. Crum, "Polyacrylamide gel as an acoustic coupling medium for focused ultrasound therapy," Ultrasound Med. Biol., vol. 29, pp. 1351-1358, 2003. https://doi.org/10.1016/S0301-5629(03)00979-7
  3. L.S. Bouchard, and M.J. Bronskill, "Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices," Med. Phys., vol. 27, pp. 1141-1145, 2000. https://doi.org/10.1118/1.598980
  4. C. Lafon, V. Zderic, M.L. Noble, J.C. Yuen, P.J. Kaczkowski, O.A. Sapozhnikov, F. Chavrier, L.A. Crum, and S. Vaezy, "Gel phantom for use in High-intensity focused ultrasound dosimetry," Ultrasound Med. Biol., vol. 31, pp. 1383-1389, 2005. https://doi.org/10.1016/j.ultrasmedbio.2005.06.004
  5. H. Ushijima, N. Senoo, J. Suzuki, M. Ichiyanagi, K. Yoshinaka, J. Deguchi, S. Takagi, T. Miyata, and Y. Matsumoto, "Measurements of HIFU-induced Lesions in BSA Gel Phantoms for HIFU Treatment of Varicose Veins of Lower Extremity," in Proc. AIP Conf., Tokyo, Japan, Jun. 2011, pp. 53-58.
  6. K. Takegami, Y. Kaneko, T. Watanabe, Y. Matsumoto, and H. Nagawa, "Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound," Ultrasound Med. Biol., vol. 30, pp. 1419-1422, 2004. https://doi.org/10.1016/j.ultrasmedbio.2004.07.016
  7. V.A. Khokhlova, M.R. Baile, J.A. Reed, B.W. Cunitz, P.J. Kaczkowski, and L.A. Crum, "Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom," J. Acoust. Soc. Am., vol. 119, pp. 1834-1848, 2006. https://doi.org/10.1121/1.2161440
  8. J. Gao, J. You, Z. Huang, S. Cochran, and G. Corner, "Simultaneous measurement of thermophysical properties of tissuemimicking phantoms for High Intensity Focused Ultrasound (HIFU) exposures," Int. J. Thermophys., vol. 33, pp. 480- 489, 2012.
  9. Y. Liu, S. Maruvada, B.A. Herman, and G.R. Harris, "Egg white as a blood coagulation surrogate," J. Acoust. Soc. Am., vol. 128, pp. 480-489, 2010. https://doi.org/10.1121/1.3442361
  10. G.W. Divkovic, and J.W. Jenne, "Egg white phantom for HIFU", in Proc. AIP Conf., Kyoto, Japan, Sep. 2004, pp. 143-146.
  11. G.W. Divkovic, M. Liebler, K. Braun, T. Dreyer, P.E. Huber, and J.W. Jenne, "Thermal properties and changes of acoustic parameters in an egg white phantom during heating and coagulation by High Intensity Focused Ultrasound," Ultrasound Med. Biol., vol. 33, pp. 981-986, 2007. https://doi.org/10.1016/j.ultrasmedbio.2006.11.021
  12. C.P. Labuda, and C.C. Church, "Augmentation of HIFUinduced heating with fibers embedded in a phantom," Ultrasound Med. Biol., vol. 3, pp. 442-449, 2011.
  13. S.R. Davidson, and M.D. Sherar, "Measurement of the thermal conductivity of polyacrylamide tissue equivalent material," Int. J. Hyperthermia, vol. 19, pp. 551-562, 2003. https://doi.org/10.1080/02656730310001607995
  14. M.G. Bini, A. Ignesti, L. Millanta, R. Olmi, N. Rubino, and R. Vanni, "The polyacrylamide as a phantom material for electromagnetic hyperthermia studies," IEEE Trans. Biomed. Eng., vol. BME-31, pp. 317-322, 1984. https://doi.org/10.1109/TBME.1984.325271
  15. IEC 60601-2-5, Medical electrical equipment-Particular requirements for the basic safety and essential performance of ultrasonic physiotherapy equipment, Geneva, Switzerland: International Electrotechnical Commission, 2009, pp. 21.
  16. ICRU report 61- Tissue substitutes, phantoms and computational modelling in medical ultrasound, Bethesda, USA: International Commission on Radiation Units and Measurements, 1998, pp. 1-132.
  17. T.D. Mast, "Empirical relationships between acoustic parameters in human soft tissues," J. Acoust. Soc. Am., vol. 1, pp. 37-42, 2000.
  18. J.Y. Kim, H.D. Jung, J.H. Min, M.S. Kim, D.J. Moon, J.Y. Kim, S.C. Noh, and H.H. Choi, "A study for the Analysis of thermal denature characteristic on tissue by using Egg-white TMM phantom" in Proc. 48th Biomedical Engineering, Incheon, Korea, Nov. 2013, pp. 57-58.
  19. C.R. Hill, and G.R. ter Haar, "Review article: High intensity focused ultrasound-potential for cancer treatment," The British J. Radiology, vol. 68, pp. 1296 -1303, 1995. https://doi.org/10.1259/0007-1285-68-816-1296
  20. D. Haemmerich, I.D. Santos, D.J. Schuttc, J.G. Websterc, and D.M. Mahvid, "In vitro measurements of temperature-dependent specific heat of liver tissue," Medical Engineering & Physics, vol. 28, pp. 194-197, 2006. https://doi.org/10.1016/j.medengphy.2005.04.020