Brotschi, Christine; Leumann, Christian J. (2005). RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes. Chemical communications(15), pp. 2023-2025. Royal Society of Chemistry 10.1039/B419278H
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Introduction of a hydrophobic biphenyl-C-nucleotide pair into a 11-mer RNA duplex is associated with a net penalty in the free energy of duplex formation of 2.0 kcal mol(-1) or 10 degrees C in T(m), relative to DNA. These differential stabilities are of relevance with respect to the transcriptional and translational aspects of hydrophobic base-pairs
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1359-7345 |
Publisher: |
Royal Society of Chemistry |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
26 May 2014 14:44 |
Last Modified: |
05 Dec 2022 14:34 |
Publisher DOI: |
10.1039/B419278H |
PubMed ID: |
15834493 |
Uncontrolled Keywords: |
base, BASE-PAIR, biphenyl, DNA, duplex, DUPLEXES, RNA, stability |
BORIS DOI: |
10.7892/boris.53097 |
URI: |
https://boris.unibe.ch/id/eprint/53097 |
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