Abstract: In order to extend the use of concealed explosive detecting device in the anti-terrorist area, the safety analysis of explosive, food and drug for the fast neutron irradiation was carried out. The Monte Carlo simulation was used to build the evaluated model of fast neutron irradiated on explosive. Combining with the energy deposition and exploded mechanisms, the fast neutron irradiation would not cause the explosive blast. The dose analysis method was used to evaluate the safety of fast neutron irradiated on food and drug. The results show that the fast neutron irradiated on food and drug is safe with the irradiation dose under the standard at home and abroad in the condition of concealed explosive detecting device.