[关键词]
[摘要]
目的 研究工业大麻Cannabis sativa地上部分的化学成分。方法 采用硅胶柱色谱及HPLC等色谱技术进行分离纯化,通过理化性质与波谱数据分析鉴定结构。结果 从工业大麻地上部分的醋酸乙酯萃取物中分离得到30个单体化合物,分别为13S-羟基-9Z,11E,15E-十八碳三烯酸甲酯(1)、Δ9-四氢次大麻酚酸(2)、二氢猕猴桃内脂(3)、苯甲酸(4)、对羟基肉桂酸甲酯(5)、二氢阿魏酸甲酯(6)、9,10-二氢-2,3,5,6-四甲氧基菲-1,4-二酮(7)、脱镁叶绿素甲酯(8)、对羟基苯甲酸(9)、大麻黄素A(10)、反式对羟基肉桂酸酰对羟基苯乙胺(11)、黑麦草素(12)、3S-羟基-5α,6α-环氧-β-紫罗兰酮(13)、大麻艾尔松酸B(14)、3-吲哚甲酸(15)、亚油酸单甘油酯(16)、反式对羟基肉桂酸(17)、松脂醇(18)、琥珀酸(19)、反式肉桂酸(20)、胡萝卜苷(21)、β-谷甾醇(22)、顺式对羟基肉桂酸(23)、顺式阿魏酸酰对羟基苯乙胺(24)、木犀草素(25)、甘油-1-(13-羟基-9Z,11E,5E-十八碳三烯酸)酯(26)、6S,9R-二羟基-3-酮-α-紫罗兰醇(27)、反式阿魏酸酰对羟基苯乙胺(28)、布卢姆醇B(29)以及儿茶素(30)。结论 化合物26为新化合物,命名为大麻三烯酸A,化合物1首次作为天然产物分离得到,化合物6、8、12、13、16、27为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from aerial part of Cannabis sativa. Methods The chemical constituents were isolated by silica gel column chromatography and HPLC, and their structures were identified by their spectral data and physicochemical properties analysis. Results Thirty compounds were isolated from C. sativa, which were identified as methyl (9Z,11E,13S,15Z)-13-hydroxyoctadeca-9,11,15-trienoate (1), cannabidivarinic acid (2), dihydroactinidiolide (3), benzoic acid (4), methyl p-hydroxycinnamate (5), dihydroferulic acid methyl ester (6), 9,10-dihydro-2,3,5,6-tetramethoxyphenanthrene-1,4-dione (7), methyl phaeophorbidea (8), p-hydroxybenzoic acid(9), cannflavin A (10), N-(trans-p-coumaroyl) tyramine (11), epiloliolide (12), 3S-hydroxy-5α,6α-epoxy-β-ionone (13), cannabielsoic acid B (14), indole-3-carboxylic acid (15), glycerin linoleat (16), trans-p-hydroxy-cinnamic acid (17), pinoresinol(18), succinic acid (19), trans-cinnamic acid (20), daucosterol (21), β-sitosterol (22), cis-p-hydroxy-cinnamic acid (23), N-(cis-feruloyl) tyramine (24), luteolin (25), glycerin-1-(13-hydroxy-9Z,11E,15E-octadecatrienoic acid)ester (26), (6S,9R)-vomifoliol (27), N-(trans-feruloyl) tyramine (28), blumenol B (29), and catechin (30). Conclusion Compound 26 is new compound named as cannabitrienoic acid A. Compound 1 is new natural product. Compounds 6, 8, 12, 13, 16, and 27 are isolated from Cannabis for the first time.
[中图分类号]
R284.1
[基金项目]
黑龙江省省属高等学校基本科研业务费科研项目(135309301)