[关键词]
[摘要]
目的 研究艾蒿Artemisia argyi的化学成分。方法 采用溶剂萃取、硅胶柱色谱、高效液相色谱等方法进行分离纯化,通过理化性质及波谱数据分析鉴定结构。结果 从艾蒿中分离得到31个化合物,分别鉴定为(E)-β-法尼烯(1)、β-香树脂醇乙酸酯(2)、环阿屯-3-醇乙酸酯(3)、羽扇豆醇乙酸酯(4)、正三十烷醇(5)、正二十二烷酸(6)、硬脂酸(7)、正二十四烷酸(8)、(2R,4aR,8aR)-3,4,4a,8a-四氢-4a-羟基-2,6,7,8a-四甲基-2-(4,8,12-三甲基十三烷基)-色烯-5,8-二酮(9)、α-菠甾醇(10)、软脂酸甘油单酯(11)、12β,20β-二羟基-达玛-23-烯-3-酮(12)、硬脂酸甘油单酯(13)、亚麻酸甘油单酯(14)、亚油酸甘油单酯(15)、油酸甘油单酯(16)、3-(3-甲基-2-丁基)苯乙酮-4-O-β-D-葡萄糖苷(17)、顺-菊烯醇-β-D-葡萄糖苷(18)、黑沙蒿苷(19)、(1S,2S,4R)-对薄荷烷-1,2,8-三醇-2-O-β-D-吡喃葡萄糖苷(20)、(2E,6R)-2,6-二甲基-2,7-辛二烯-6-羟基-1-O-β-D-葡萄糖苷(21)、白蔹苷(22)、对羟基苯乙酮葡萄糖苷(23)、茵芋苷(24)、东莨菪苷(25)、菊花苷B(26)、(4R)-对薄荷-1-烯-7,8-二醇-7-O-β-D-葡萄糖苷(27)、(4R)-对薄荷-7,8-二醇-7-O-β-D-葡萄糖苷(28)、异野漆树苷(29)、1,3-O-二咖啡酰基奎宁酸(30)、右旋肌醇甲醚(31)。结论 化合物1、9、17、20、21、26、28为首次从蒿属植物中分离得到,化合物11、12、14~16、18、19、23、24、27、30、31为首次从艾蒿中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Artemisia argyi. Methods The chemical constituents were isolated by silica gel column chromatography and HPLC, and its structure were identified by their spectral data and physicochemical properties analysis. Result Thirty-one compounds were isolated from A. argyi with the structures identified as (E)-β-farnesene (1), β-amyrin acetate (2), cycloartenol acetate (3), lupelo acetate (4), n-triacontanol (5), docosanoic acid (6), octadecanoic acid (7), tetracosanoic acid (8), (2R,4aR,8aR)-3,4,4a,8a-tetrahydro-4a-hydroxy-2,6,7,8a-tetramethyl-2-(4,8,12-trimethyl)-chromene-5,8-dione (9), α-spinasterol (10), monopalmitin (11), 12β,20β-dihydroxyldamar-23-en-3-ketone (12), monostearin (13), monolinolenin (14), monolinolein (15), monoolein (16), 3-(3-methyl-2-butenyl)acetophenone-4-O-β-D-glucoside (17), (-)cis-chrysan-thenol-β-D-glucoside (18), artemisioside (19), (1S,2S,4R)-p-menthane-1,2,8-triol-2-O-glucoside (20), (2E,6R)-2,6-dimethyl-2,7-octadiene-6-hydroxy-1-O-glycoside (21), ampelopsisionoside (22), 4-hydroxy acetophenone-4-O-β-D-glucoside (23), skimmin (24), scopoletin (25), dendanthemoside B (26), (4R)-p-menth-1-ene-7,8-diol-7-O-β-D-glucoside (27), (4R)-p-menthane-7,8-diol-7-O-β-D-glucoside (28), isorhoifolin (29), 1,3-dicaffeoylquinic acid (30) and pinitol (31). Conclusion Compounds 1, 9, 17, 20, 21, 26, 28 are separated from Artemisia genus for the first time. Compounds 11, 12, 14-16, 18, 19, 23, 24, 27, 30, 31 are isolated from A. argyi for the first time.
[中图分类号]
R284.1
[基金项目]
黑龙江省教育厅基本业务专项理工重点项目(135209101)