目的 研究石山巴豆Croton euryphyllus枝叶中的二萜成分。方法 综合运用硅胶、MCI、高效液相等色谱技术进行化合物的分离纯化，根据化合物的波谱数据分析与文献比对进行结构鉴定。结果 从石山巴豆枝叶95%提取物的石油醚部位中分离得到4个化合物，分别鉴定为crotoeurin D（1）、mallotucin C（2）、mallotucin D（3）、plaunotol（4）。结论 化合物1为新的降克罗烷二萜，命名为石山巴豆素D；化合物2~4均为首次从该植物中分离得到。

Objective To study the diterpenoids from the twigs and leaves of Croton euryphyllus. Methods Compounds were isolated and purified by column chromatography on silica gel, MCI, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analysis and comparisons with published literature values. Results Four compounds were obtained from the petroleum ether fraction of 95% alcoholic extract of the twigs and leaves of C. euryphyllus, and structures were identified as crotoeurin D (1), mallotucin C (2), mallotucin D (3), and plaunotol (4), respectively. Conclusion Compound 1 is a new norclerodan diterpene. Compounds 2 -4 are isolated from this plant for the first time.

国家自然科学基金资助项目（21102023）；广西自然科学基金资助项目（2011GXNSFB018022）；中国科学院"西部之光"人才培养计划项目（2012）；广西科技重大专项资助项目（桂科AA18118015-4）