7.25, with 30 neonates in each group. aEEG mornitoring was performed within 6 hours after birth, and the abnormal rate of aEEG findings and average cerebral function monitoring (CFM) score were compared between groups. Results The pH ≤ 7.15 group had a significantly higher abnormal rate of aEEG findings than the pH >7.25 group (P < 0.0167) and a significantly lower aEEG CFM score than the 7.15
7.25 groups (P < 0.05). Peripheral blood pH was positively correlated with the CFM score (r=0.26, P < 0.05). Conclusions Peripheral blood pH is significantly associated with aEEG findings in neonates with intrauterine distress. Active measures should be adopted for the prevention and treatment of nervous system injury in neonates with intrauterine distress who have a significant reduction in peripheral blood pH early after birth (pH ≤ 7.15)."/>
宫内窘迫新生儿生后早期外周血pH值与振幅整合脑电图结果的关系
Abstract：Objective To study the association of peripheral blood pH early after birth with amplitude-integrated electroencephalography (aEEG) findings in neonates with intrauterine distress. Methods The clinical data of the neonates with intrauterine distress who were born from January 2017 to May 2018 were collected. According to peripheral blood pH within 30 minutes after birth, these neonates were divided into 3 groups:pH ≤ 7.15, 7.15
7.25, with 30 neonates in each group. aEEG mornitoring was performed within 6 hours after birth, and the abnormal rate of aEEG findings and average cerebral function monitoring (CFM) score were compared between groups. Results The pH ≤ 7.15 group had a significantly higher abnormal rate of aEEG findings than the pH >7.25 group (P < 0.0167) and a significantly lower aEEG CFM score than the 7.15
7.25 groups (P < 0.05). Peripheral blood pH was positively correlated with the CFM score (r=0.26, P < 0.05). Conclusions Peripheral blood pH is significantly associated with aEEG findings in neonates with intrauterine distress. Active measures should be adopted for the prevention and treatment of nervous system injury in neonates with intrauterine distress who have a significant reduction in peripheral blood pH early after birth (pH ≤ 7.15).
ZHANG Hong-Qin,HUANG Lu,CHEN Jun et al. Association of peripheral blood pH early after birth with amplitude-integrated electroencephalography findings in neonates with intrauterine distress[J]. CJCP, 2019, 21(5): 454-457.
Bullens LM, van Runnard Heimel PJ, van der Hout-van der Jagt MB, et al. Interventions for intrauterine resuscitation in suspected fetal distress during term labor:a systematic review[J]. Obstet Gynecol Surv, 2015, 70(8):524-539.
Burdjalov VF, Baumgart S, Spitzer AR. Cerebral function monitoring:a new scoring system for the evaluation of brain maturation in neonates[J]. Pediatrics, 2003, 112(4):855-861.
Hellström-Westas L, Rosén I, Svenningsen NW. Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants[J]. Arch Dis Child Fetal Neonatal Ed, 1995, 72(1):F34-F38.
da Silva S, Hennebert N, Denis R, et al. Clinical value of a single postnatal lacate measurement after intrapartum asphyxia[J]. Acta Paediatr, 2000, 89(3):320-323.
Casey BM, Goldaber KG, McIntire DD, et al. Outcomes among term infants when two-hour postnatal pH is compared with pH at delivery[J]. Am J Obstetr Gynecol, 2001, 184(3):447-450.
Awal MA, Lai MM, Azemi G, et al. EEG background features that predict outcome in term neonates with hypoxic ischaemic encephalopathy:a structured review[J]. Clin Neurophysiol, 2016, 127(1):285-296.
[19]
Murray DM, O'Connor CM, Ryan CA, et al. Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy[J]. Pediatrics, 2016, 138(4). pii:e20160659.
