Evaluation of the renoprotective effect of syringic acid against nephrotoxicity induced by cisplatin in rats

Hardevinder Pal Singh; Thakur Gurjeet Singh; Randhir Singh

doi:10.7324/JAPS.2021.11s109

Abstract References Article Metrics Similar Articles Request Permission Related Search Citation Alert By Google Scholar Comment On This Article

Abstract

The present study investigated the role of syringic acid (SA) in the renal protection mediated through the nitric oxide synthase (NOS) pathway in rodents treated with cisplatin (CP) with a single nephrotoxic dose of 5 mg/kg (i.p.) on the day the study commenced. The nephrotoxicity caused by a single dose of CP was assessed by measuring renal functional test (in serum and urine), oxidative stress parameters, and histopathological evaluation with hematoxylin and eosin stain in renal tissue on day 5, i.e., the last day of the study. The Administration of SA provides significant (p < 0.05) dose-mediated (50 and 100 mg/kg, p.o.) nephroprotection in CP-treated male Wistar rats. Pretreatment with NOS inhibitor, L-nitroarginine methyl ester (20 mg/kg, i.p.) in rats abolished the nephroprotective prospective of SA. SA-mediated activation of the NOS pathway has been hypothesized to contribute to renoprotection.

Keyword: Cisplatin nephrotoxicity oxidative stress syringic acid nitric oxide synthase.

Citation:

Singh HP, Singh TG, Singh R. Evaluation of the renoprotective effect of syringic acid against nephrotoxicity induced by cisplatin in rats. J Appl Pharm Sci, 2021; 11 (Supp 1):080–085.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Abdel Moneim AE, Othman MS, Aref AM. Azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. Biomed Res Int, 2014; 2014:647131. https://doi.org/10.1155/2014/647131
Alhoshani AR, Hafez MM, Husain S, Al-Sheikh AM, Alotaibi MR, Al Rejaie SS, Alshammari MA, Almutairi MM, Al-Shabanah OA. Protective effect of rutin supplementation against cisplatin-induced nephrotoxicity in rats. BMC Nephrol, 2017; 18(1):194. https://doi.org/10.1186/s12882-017-0601-y
Arab HH, Salama SA, Maghrabi IA. Camel milk ameliorates 5-Fluorouracil-induced renal injury in rats: targeting MAPKs, NF-κB and PI3K/Akt/eNOS pathways. Cell Physiol Biochem, 2018; 46(4):1628-42. https://doi.org/10.1159/000489210
Cherla G, Jaimes EA. Role of L-arginine in the pathogenesis and treatment of renal disease. J Nutr, 2004; 134(10 Suppl):2801S-6S. https://doi.org/10.1093/jn/134.10.2801S
Cikman O, Soylemez O, Ozkan OF, Kiraz HA, Sayar I, Ademoglu S, Taysi S, Karaayvaz M. Antioxidant activity of syringic acid prevents oxidative stress in l-arginine-induced acute pancreatitis: an experimental study on rats. Int Surg, 2015; 100(5):891-6. https://doi.org/10.9738/INTSURG-D-14-00170.1
Czambel RK, Kharlamov A, Jones SC. Variations of brain endothelial nitric oxide synthase concentration in rat and mouse cortex. Nitric Oxide, 2010; 22(1):51-7. https://doi.org/10.1016/j.niox.2009.11.006
Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA, Khan F. Protective effect of nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. Biomed Pharmacother, 2017; 85:7-15. https://doi.org/10.1016/j.biopha.2016.11.110
Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatininduced acute renal failure is associated with an increase in the cytokines interleukin(IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007; 322(1):8-15. https://doi.org/10.1124/jpet.107.119792
Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 1980; 288(5789):373-6. https://doi.org/10.1038/288373a0
Gharibi F, Soltani N, Maleki M, Talebi A, Nasiri M, Shirdavani S, Nematbakhsh M. The protective effect of l-arginine in cisplatin-induced nephrotoxicity in streptozotocin-induced diabetic rats. Adv Biomed Res, 2017; 6:100. https://doi.org/10.4103/2277-9175.212928
Hopkins N, Cadogan E, Giles S, Bannigan J, McLoughlin P. Type 2 nitric oxide synthase and protein nitration in chronic lung infection. J Pathol, 2003; 199(1):122-9. https://doi.org/10.1002/path.1256
Izzedine H, Perazella MA. Anticancer drug-induced acute kidney injury. Kidney Int Rep, 2017; 2(4):504-14. https://doi.org/10.1016/j.ekir.2017.02.008
Jilanchi S, Talebi A, Nematbakhsh M. Cispaltin alters sodium excertion and renal clearance in rats: gender and drug dose related. Adv Biomed Res, 2018; 7:54. https://doi.org/10.4103/abr.abr_124_17
Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia, 2012; 83(4):650-9. https://doi.org/10.1016/j.fitote.2012.01.010
Kapil A, Singh JP, Kaur T, Singh B, Singh AP. Involvement of peroxisome proliferator-activated receptor gamma in vitamin-D mediated protection against acute kidney injury in rats. J Surg Res, 2013; 185(2): 774-83. https://doi.org/10.1016/j.jss.2013.07.017
Kilic U, Kilic E, Tuzcu Z, Tuzcu M, Ozercan IH, Yilmaz O, Sahin F, Sahin K. Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway. Nutr Metab (Lond). 2013; 10(1):7. https://doi.org/10.1186/1743-7075-10-7
Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimentalnephrotoxicity. J Agric Food Chem, 2007; 55(25):10150-5. https://doi.org/10.1021/jf0723965
Kumar S, Prahalathan P, Raja B. Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. Naunyn Schmiedebergs Arch Pharmacol, 2012; 385(12):1175-84. https://doi.org/10.1007/s00210-012-0802-7
Liu JQ, Cai GY, Wang SY, Song YH, Xia YY, Liang S, Wang W, Nie S, Feng Z, Chen X. The characteristics and risk factors for cisplatininduced acute kidney injury in the elderly. Ther Clin Risk Manag, 2018; 14:1279-85. https://doi.org/10.2147/TCRM.S165531
Manohar S, Leung N. Cisplatin nephrotoxicity: a review of the literature. J Nephrol, 2018; 31(1):15-25. https://doi.org/10.1007/s40620-017-0392-z
Murohara T, Witzenbichler B, Spyridopoulos I, Asahara T, Ding B, Sullivan A, Losordo DW, Isner JM. Role of endothelial nitric oxide synthase in endothelial cell migration. Arterioscler Thromb Vasc Biol, 1999; 19(5):1156-61. ttps://doi.org/10.1161/01.ATV.19.5.1156
Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, Ashrafi F. Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female. Nephrourol Mon, 2013; 5(3):818-21. https://doi.org/10.5812/numonthly.10128
Noori S, Mahboob T. Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats. Indian J Clin Biochem, 2010; 25(1):86-91. https://doi.org/10.1007/s12291-010-0018-x
Ozturk H, Firat T, Tekce BK, Yilmaz F. Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction. Kaohsiung J Med Sci, 2017;33:236-45. https://doi.org/10.1016/j.kjms.2017.03.003
Peres LA, da Cunha AD Jr. Acute nephrotoxicity of cisplatin: molecular mechanisms. J Bras Nefrol, 2013; 35(4):332-40. https://doi.org/10.5935/0101-2800.20130052
Ramachandran V, Raja B. Protective effects of syringic acid against acetaminophen induced hepatic damage in albino rats. J Basic Clin Physiol Pharmacol, 2010; 21(4):369-85. https://doi.org/10.1515/JBCPP.2010.21.4.369
Ramesh G, Reeves WB. TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest. 2002; 110(6):835-42. https://doi.org/10.1172/JCI200215606
Sancaktutar AA, Bodakci MN, Hatipoglu NK, Soylemez H, BasarÄ±lÄ± K, Turkcu G. The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in malerats. Urol Ann, 2014; 6(1):46-50. https://doi.org/10.4103/0974-7796.127029
Sehajpal J, Kaur T, Bhatti R, Singh AP. Role of progesterone in melatonin-mediated protection against acute kidney injury. J Surg Res, 2014; 191(2):441-7. https://doi.org/10.1016/j.jss.2014.04.025
Shahzad S, Mateen S, Naeem SS, Akhtar K, Rizvi W, Moin S. Syringic acid protects from isoproterenol induced cardiotoxicity in rats. Eur J Pharmacol, 2019; 849:135-45. https://doi.org/10.1016/j.ejphar.2019.01.056
Singh S, Singh TG. Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach. Curr Neuropharmacol. 2020; 18(10):918-35. https://doi.org/10.2174/1570159X18666200207120949
Singh AP, Singh N, Pathak D, Bedi PMS. Estradiol attenuates ischemia reperfusion-induced acute kidney injury through PPAR-γ stimulated eNOS activation in rats. Mol Cell Biochem. 2019; 453(1-2):1-9. https://doi.org/10.1007/s11010-018-3427-4
Singh HP, Singh TG, Singh R. Sinapic acid attenuates cisplatininduced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats. J Pharm Bioallied Sci. 2020; 12(2):146-54. https://doi.org/10.4103/jpbs.JPBS_220_19
Singh TG, Singh HP, Kaur S, Dhiman S. Protective effects of sesamol against cisplatin-induced nephrotoxicity in rats: a mechanistic approach. Obes Med, 2020; 19:100269. https://doi.org/10.1016/j.obmed.2020.100269
Srinivasulu C, Ramgopal M, Ramanjaneyulu G, Anuradha CM, Suresh Kumar C. Syringic acid (SA) - A review of its occurrence, biosynthesis, pharmacological and industrial importance. Biomed Pharmacother, 2018; 108:547-57. https://doi.org/10.1016/j.biopha.2018.09.069
Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. J Pharm Pharmacol, 2012; 64(6):872-81. https://doi.org/10.1111/j.2042-7158.2012.01470.x
Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem, 1994; 269(7):4705-8. https://doi.org/10.1016/S0021-9258(17)37600-7
Zhang F, Siow YL, Karmin O. Hyperhomocysteinemia activates NF-κB and inducible nitric oxide synthase in the kidney. Kidney Int, 2004; 65(4):1327-38. https://doi.org/10.1111/j.1523-1755.2004.00510.x

Article Metrics

484 Views 60 Downloads 544 Total

Year

Month

Related Search

By author names

Singh H P [PubMed] [Google Scholar ]

Singh T G [PubMed] [Google Scholar ]

Singh R [PubMed] [Google Scholar ]

By article title

Abdel Moneim AE, Othman MS, Aref AM. Azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. Biomed Res Int, 2014; 2014:647131. https://doi.org/10.1155/2014/647131

Alhoshani AR, Hafez MM, Husain S, Al-Sheikh AM, Alotaibi MR, Al Rejaie SS, Alshammari MA, Almutairi MM, Al-Shabanah OA. Protective effect of rutin supplementation against cisplatin-induced nephrotoxicity in rats. BMC Nephrol, 2017; 18(1):194. https://doi.org/10.1186/s12882-017-0601-y

Arab HH, Salama SA, Maghrabi IA. Camel milk ameliorates 5-Fluorouracil-induced renal injury in rats: targeting MAPKs, NF-κB and PI3K/Akt/eNOS pathways. Cell Physiol Biochem, 2018; 46(4):1628-42. https://doi.org/10.1159/000489210

Cherla G, Jaimes EA. Role of L-arginine in the pathogenesis and treatment of renal disease. J Nutr, 2004; 134(10 Suppl):2801S-6S. https://doi.org/10.1093/jn/134.10.2801S

Cikman O, Soylemez O, Ozkan OF, Kiraz HA, Sayar I, Ademoglu S, Taysi S, Karaayvaz M. Antioxidant activity of syringic acid prevents oxidative stress in l-arginine-induced acute pancreatitis: an experimental study on rats. Int Surg, 2015; 100(5):891-6. https://doi.org/10.9738/INTSURG-D-14-00170.1

Czambel RK, Kharlamov A, Jones SC. Variations of brain endothelial nitric oxide synthase concentration in rat and mouse cortex. Nitric Oxide, 2010; 22(1):51-7. https://doi.org/10.1016/j.niox.2009.11.006

Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA, Khan F. Protective effect of nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. Biomed Pharmacother, 2017; 85:7-15. https://doi.org/10.1016/j.biopha.2016.11.110

Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatininduced acute renal failure is associated with an increase in the cytokines interleukin(IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007; 322(1):8-15. https://doi.org/10.1124/jpet.107.119792

Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 1980; 288(5789):373-6. https://doi.org/10.1038/288373a0

Gharibi F, Soltani N, Maleki M, Talebi A, Nasiri M, Shirdavani S, Nematbakhsh M. The protective effect of l-arginine in cisplatin-induced nephrotoxicity in streptozotocin-induced diabetic rats. Adv Biomed Res, 2017; 6:100. https://doi.org/10.4103/2277-9175.212928

Hopkins N, Cadogan E, Giles S, Bannigan J, McLoughlin P. Type 2 nitric oxide synthase and protein nitration in chronic lung infection. J Pathol, 2003; 199(1):122-9. https://doi.org/10.1002/path.1256

Izzedine H, Perazella MA. Anticancer drug-induced acute kidney injury. Kidney Int Rep, 2017; 2(4):504-14. https://doi.org/10.1016/j.ekir.2017.02.008

Jilanchi S, Talebi A, Nematbakhsh M. Cispaltin alters sodium excertion and renal clearance in rats: gender and drug dose related. Adv Biomed Res, 2018; 7:54. https://doi.org/10.4103/abr.abr_124_17

Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia, 2012; 83(4):650-9. https://doi.org/10.1016/j.fitote.2012.01.010

Kapil A, Singh JP, Kaur T, Singh B, Singh AP. Involvement of peroxisome proliferator-activated receptor gamma in vitamin-D mediated protection against acute kidney injury in rats. J Surg Res, 2013; 185(2): 774-83. https://doi.org/10.1016/j.jss.2013.07.017

Kilic U, Kilic E, Tuzcu Z, Tuzcu M, Ozercan IH, Yilmaz O, Sahin F, Sahin K. Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway. Nutr Metab (Lond). 2013; 10(1):7. https://doi.org/10.1186/1743-7075-10-7

Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimentalnephrotoxicity. J Agric Food Chem, 2007; 55(25):10150-5. https://doi.org/10.1021/jf0723965

Kumar S, Prahalathan P, Raja B. Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. Naunyn Schmiedebergs Arch Pharmacol, 2012; 385(12):1175-84. https://doi.org/10.1007/s00210-012-0802-7

Liu JQ, Cai GY, Wang SY, Song YH, Xia YY, Liang S, Wang W, Nie S, Feng Z, Chen X. The characteristics and risk factors for cisplatininduced acute kidney injury in the elderly. Ther Clin Risk Manag, 2018; 14:1279-85. https://doi.org/10.2147/TCRM.S165531

Manohar S, Leung N. Cisplatin nephrotoxicity: a review of the literature. J Nephrol, 2018; 31(1):15-25. https://doi.org/10.1007/s40620-017-0392-z

Murohara T, Witzenbichler B, Spyridopoulos I, Asahara T, Ding B, Sullivan A, Losordo DW, Isner JM. Role of endothelial nitric oxide synthase in endothelial cell migration. Arterioscler Thromb Vasc Biol, 1999; 19(5):1156-61. ttps://doi.org/10.1161/01.ATV.19.5.1156

Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, Ashrafi F. Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female. Nephrourol Mon, 2013; 5(3):818-21. https://doi.org/10.5812/numonthly.10128

Noori S, Mahboob T. Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats. Indian J Clin Biochem, 2010; 25(1):86-91. https://doi.org/10.1007/s12291-010-0018-x

Ozturk H, Firat T, Tekce BK, Yilmaz F. Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction. Kaohsiung J Med Sci, 2017;33:236-45. https://doi.org/10.1016/j.kjms.2017.03.003

Peres LA, da Cunha AD Jr. Acute nephrotoxicity of cisplatin: molecular mechanisms. J Bras Nefrol, 2013; 35(4):332-40. https://doi.org/10.5935/0101-2800.20130052

Ramachandran V, Raja B. Protective effects of syringic acid against acetaminophen induced hepatic damage in albino rats. J Basic Clin Physiol Pharmacol, 2010; 21(4):369-85. https://doi.org/10.1515/JBCPP.2010.21.4.369

Ramesh G, Reeves WB. TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest. 2002; 110(6):835-42. https://doi.org/10.1172/JCI200215606

Sancaktutar AA, Bodakci MN, Hatipoglu NK, Soylemez H, BasarÄ±lÄ± K, Turkcu G. The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in malerats. Urol Ann, 2014; 6(1):46-50. https://doi.org/10.4103/0974-7796.127029

Sehajpal J, Kaur T, Bhatti R, Singh AP. Role of progesterone in melatonin-mediated protection against acute kidney injury. J Surg Res, 2014; 191(2):441-7. https://doi.org/10.1016/j.jss.2014.04.025

Shahzad S, Mateen S, Naeem SS, Akhtar K, Rizvi W, Moin S. Syringic acid protects from isoproterenol induced cardiotoxicity in rats. Eur J Pharmacol, 2019; 849:135-45. https://doi.org/10.1016/j.ejphar.2019.01.056

Singh S, Singh TG. Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach. Curr Neuropharmacol. 2020; 18(10):918-35. https://doi.org/10.2174/1570159X18666200207120949

Singh AP, Singh N, Pathak D, Bedi PMS. Estradiol attenuates ischemia reperfusion-induced acute kidney injury through PPAR-γ stimulated eNOS activation in rats. Mol Cell Biochem. 2019; 453(1-2):1-9. https://doi.org/10.1007/s11010-018-3427-4

Singh HP, Singh TG, Singh R. Sinapic acid attenuates cisplatininduced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats. J Pharm Bioallied Sci. 2020; 12(2):146-54. https://doi.org/10.4103/jpbs.JPBS_220_19

Singh TG, Singh HP, Kaur S, Dhiman S. Protective effects of sesamol against cisplatin-induced nephrotoxicity in rats: a mechanistic approach. Obes Med, 2020; 19:100269. https://doi.org/10.1016/j.obmed.2020.100269

Srinivasulu C, Ramgopal M, Ramanjaneyulu G, Anuradha CM, Suresh Kumar C. Syringic acid (SA) - A review of its occurrence, biosynthesis, pharmacological and industrial importance. Biomed Pharmacother, 2018; 108:547-57. https://doi.org/10.1016/j.biopha.2018.09.069

Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. J Pharm Pharmacol, 2012; 64(6):872-81. https://doi.org/10.1111/j.2042-7158.2012.01470.x

Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem, 1994; 269(7):4705-8. https://doi.org/10.1016/S0021-9258(17)37600-7

Zhang F, Siow YL, Karmin O. Hyperhomocysteinemia activates NF-κB and inducible nitric oxide synthase in the kidney. Kidney Int, 2004; 65(4):1327-38. https://doi.org/10.1111/j.1523-1755.2004.00510.x