Research Article | Volume: 5, Issue: 12, December, 2015
Research Article | Volume: 5, Issue: 12, December, 2015
In recent years azo functionalized polymeric hydrogels are very interesting; it is due to their promising applications in various fields especially in the colon drug delivery. 4-Hydroxyphenylazo-3-N-(4-hydroxyphenyl) maleimide (HPM) was synthesized and used for development of hydrogels by free radical polymerization with acrylamide (Am) and N,N-methylene bis acrylamide. Synthesized poly(Am-co-HPM) (PAH) hydrogels were used for encapsulation of 5-fluorouracil (5-FU) an anticancer drug. Structural, thermal, morphological and drug distribution of PAH hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction techniques, respectively. Maximum percentage of encapsulation efficiency i.e. 78.25±1.3 was observed for AZ1 PAH hydrogels. 5-FU release studies were performed by in vitro method in simulated gastro intestinal fluids (pH 1.2 & 7.4). To support the 5-FU release mechanism from PAH hydrogels, swelling and deswelling kinetics were studied in doubly distilled water.
Reddy PRS, Krishna Rao KSV, Rao KM, Reddy NS. Synthesis of Novel Hydrogels based Poly (4-Hydroxyphenylazo-3-N-(4- hydroxyphenyl)maleimide) for Specific Colon Delivery of Chemotherapeutic Agent. J App Pharm Sci, 2015; 5 (12): 021-028.
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