Oxaspirodion, a New Inhibitor of Inducible TNF-α Expression from the Ascomycete Chaetomium subspirale
Production, Isolation and Structure Elucidation
2004 Volume 57 Issue 8 Pages 493-495
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2004 Volume 57 Issue 8 Pages 493-495
In a search for new inhibitors of the TNF-α promoter activity, a new spiro-compound, designated oxaspirodion, was obtained as a mixture of four isomers from fermentations of the ascomycete Chaetomium subspirale. The structure was determined by a combination of spectroscopic techniques.
