The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Quinoxapeptins: Novel Chromodepsipeptide Inhibitors of HIV-1 and HIV-2 Reverse Transcriptase
I. The Producing Organism and Biological Activity
RUSSELL B. LINGHAM, AMY H. M. Hsu, JULIE A. O'BRIEN, JANET M. SIGMUND, MANUEL SANCHEZ, MAGDA M. GAGLIARDI, BRIAN K. HEIMBUCH, OLGA GENILLOUD, ISABEL MARTIN, MARIA T. DIEZ, CHARLES F. HIRSCH, DEBORAH L. ZINK, JERROLD M. LIESCH, GREGORY E. KOCH, SUZANNE E. GARTNER, GEORGE M. GARRITY, NANCY N. Tsou, GINO M. SALITURO
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JOURNAL FREE ACCESS

1996 Volume 49 Issue 3 Pages 253-259

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Abstract

Quinoxapeptm A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins A and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quinoxapeptin A and B are specific inhibitors of HIV-1 and HIV-2 reverse transcriptase because they did not inhibit human DNA polymerase α, β, γ and δ. Quinoxapeptin A and B are structurally similar to luzopeptin A which was also active against HIV-1 and HIV-2 reverse transcriptase.

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The Journal of Antibiotics, Series A

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