LACTIMIDOMYCIN, A NEW GLUTARIMIDE GROUP ANTIBIOTIC PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

KOKO SUGAWARA; YUJI NISHIYAMA; SOICHIRO TODA; NOBUJIRO KOMIYAMA; MASAMI HATORI; TOSHIO MORIYAMA; YOSUKE SAWADA; HIDEO KAMEI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1433

LACTIMIDOMYCIN, A NEW GLUTARIMIDE GROUP ANTIBIOTIC

PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

KOKO SUGAWARA, YUJI NISHIYAMA, SOICHIRO TODA, NOBUJIRO KOMIYAMA, MASAMI HATORI, TOSHIO MORIYAMA, YOSUKE SAWADA, HIDEO KAMEI, MASATAKA KONISHI, TOSHIKAZU OKI

Author information

KOKO SUGAWARA
Bristol-Myers Squibb Research Institute
YUJI NISHIYAMA
Bristol-Myers Squibb Research Institute
SOICHIRO TODA
Bristol-Myers Squibb Research Institute
NOBUJIRO KOMIYAMA
Bristol-Myers Squibb Research Institute
MASAMI HATORI
Bristol-Myers Squibb Research Institute
TOSHIO MORIYAMA
Bristol-Myers Squibb Research Institute
YOSUKE SAWADA
Bristol-Myers Squibb Research Institute
HIDEO KAMEI
Bristol-Myers Squibb Research Institute
MASATAKA KONISHI
Bristol-Myers Squibb Research Institute
TOSHIKAZU OKI
Bristol-Myers Squibb Research Institute

JOURNAL FREE ACCESS

1992 Volume 45 Issue 9 Pages 1433-1441

DOI https://doi.org/10.7164/antibiotics.45.1433

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Abstract

Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.

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