ISOLATION, CHARACTERIZATION AND STRUCTURES OF PA-46101 A AND B

MAKOTO MATSUMOTO; YOSHIMI KAWAMURA; YOHKO YOSHIMURA; YOSHIHIRO TERUI; HIROSHI NAKAI; TADASHI YOSHIDA; JUN'ICHI SHOJI

doi:10.7164/antibiotics.43.739

MAKOTO MATSUMOTO, YOSHIMI KAWAMURA, YOHKO YOSHIMURA, YOSHIHIRO TERUI, HIROSHI NAKAI, TADASHI YOSHIDA, JUN'ICHI SHOJI

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 7 Pages 739-747

DOI https://doi.org/10.7164/antibiotics.43.739

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Abstract

New antibiotics, PA-46101 A and B, were isolated from the culture broth of a Streptomycete. The molecular formulae of A and B were determined to be C₅₂H₇₀O₁₈ and C₆₁H₈₆O₂₂, -respectively, by elemental analyses, NMR and mass spectrometry. Their structures were elucidated by X-ray crystallography and NMR spectroscopy. These antibiotics are active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also against a limited number of aerobic Gram-positive bacteria.

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