The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Sch 36605, A NOVEL ANTI-INFLAMMATORY COMPOUND
TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
VINCENT GULLO, MICHAEL CONOVER, RAYMOND COOPER, CLAIRE FEDERBUSH, ANN C. HORAN, TED KUNG, JOSEPH MARQUEZ, MAHESH PATEL, ARTHUR WATNICK
Author information
JOURNAL FREE ACCESS

1988 Volume 41 Issue 1 Pages 20-24

Details
Abstract

A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as blasticidin S, demonstrated anti-inflammatory activity in the reverse passive Arthus reaction and the adjuvant arthritic rat at doses ranging between 1-10mg/kg and 0.3-6.0 mg/kg, respectively. A minor component, Sch 36606, co-produced in the fermentation was isolated and identified as a known compound in the blasticidin family of compounds.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Journal of Antibiotics, Series A

Share this page
feedback
 Top