A NOVEL MACROLIDE ANTIBIOTIC, NOTONESOMYCIN A

TORU SASAKI; KEIKO FURIHATA; AKIRA SHIMAZU; HARUO SETO; MICHIAKI IWATA; TETSURO WATANABE; NOBORU OTAKE

doi:10.7164/antibiotics.39.502

TORU SASAKI, KEIKO FURIHATA, AKIRA SHIMAZU, HARUO SETO, MICHIAKI IWATA, TETSURO WATANABE, NOBORU OTAKE

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 4 Pages 502-509

DOI https://doi.org/10.7164/antibiotics.39.502

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Abstract

Fermentation of Streptomyces aminophilus subsp. notonesogenes 647-AV1 produced a mixture of antifungal antibiotics. Notonesomycin A, the main component has been characterized as a new macrolide antibiotic containing a sulfate group, a malonate moiety, two deoxysugars and a 1, 3, 4-trisubstituted benzene system in the molecule. It was active against some fungi and Gram-positive bacteria in vitro and effective against the sheath blight disease of rice plant in a green house test.

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