OF4949, NEW INHIBITORS OF AMINOPEPTIDASE B I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

SUSUMU SANO; KATSUSHIGE IKAI; HIROYUKI KURODA; TERUYA NAKAMURA; AKIRA OBAYASHI; YOHJI EZURE; HIROSHI ENOMOTO

doi:10.7164/antibiotics.39.1674

OF4949, NEW INHIBITORS OF AMINOPEPTIDASE B

I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

SUSUMU SANO, KATSUSHIGE IKAI, HIROYUKI KURODA, TERUYA NAKAMURA, AKIRA OBAYASHI, YOHJI EZURE, HIROSHI ENOMOTO

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 12 Pages 1674-1684

DOI https://doi.org/10.7164/antibiotics.39.1674

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Abstract

New aminopeptidase B inhibitors that we named OF4949-I, II, III and IV were isolated from the culture broth of a fungus, Penicillium rugulosum OF4949. The molecular formula of I was C₂₃H₂₆N₄O₈ and that of II, C₂₂H₂₄N₄O₈, judging from elemental analysis and secondary ion mass spectrometry. The concentrations of I, II, III and IV required for 50% inhibition of aminopeptidase, using Ehrlich ascites carcinoma cells as the source of the enzyme, were 0.0054, 0.0048, 3.4 and 1.7 μg/ml, respectively. Components I and II augmented delayed-type hypersensitivity in mice to sheep red blood cells.

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