EFFECTS OF CATIONS, POLYAMINES AND OTHER AMINOGLYCOSIDES ON GENTAMICIN C2 BINDING TO RIBOSOMES FROM SENSITIVE AND RESISTANT <i>ESCHERICHIA COLI</i> STRAINS

M. MOUKADDEM; F. TANGY; M. L. CAPMAU; F. LE GOFFIC

doi:10.7164/antibiotics.39.136

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

EFFECTS OF CATIONS, POLYAMINES AND OTHER AMINOGLYCOSIDES ON GENTAMICIN C₂

BINDING TO RIBOSOMES FROM SENSITIVE AND RESISTANT ESCHERICHIA COLI STRAINS

M. MOUKADDEM, F. TANGY, M. L. CAPMAU, F. LE GOFFIC

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 1 Pages 136-140

DOI https://doi.org/10.7164/antibiotics.39.136

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Abstract

Gentamicin C₂ interacts cooperatively with ribosomes from a sensitive Escherichia coli strain in a multiphasic way with several classes of sites. It is shown that this binding is highly-dependent on Mg⁺⁺ and natural endogenous polyamine concentrations. The differences observed between ribosomes from sensitive and resistant strains may be explained by the absence of specific cooperative gentamicin interactions with resistant ribosomes. The effects of other aminoglycoside antibiotics are discussed in terms of structure-activity relationships.

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