TEICOPLANIN, ANTIBIOTICS FROM ACTINOPLANES TEICHOMYCETICUS NOV. SP. VI. CHEMICAL DEGRADATION: PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF ACID HYDROLYSIS PRODUCTS

ADRIANO MALABARBA; PAOLO STRAZZOLINI; ADELE DEPAOLI; MAURO LANDI; MARISA BERTI; BRUNO CAVALLERI

doi:10.7164/antibiotics.37.988

TEICOPLANIN, ANTIBIOTICS FROM ACTINOPLANES TEICHOMYCETICUS NOV. SP.

VI. CHEMICAL DEGRADATION: PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF ACID HYDROLYSIS PRODUCTS

ADRIANO MALABARBA, PAOLO STRAZZOLINI, ADELE DEPAOLI, MAURO LANDI, MARISA BERTI, BRUNO CAVALLERI

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 9 Pages 988-999

DOI https://doi.org/10.7164/antibiotics.37.988

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Abstract

Teicoplanin is an antibiotic complex consisting of five closely related factors, T-A2-1, 2, 3, 4 and 5 and a more polar factor, T-A3-1. By controlled acid hydrolysis the complex is transformed into pseudoaglycones and finally into a single aglycone with consecutive removal of three sugar units. Quantitative determination of sugars obtained by degradative reactions and NMR/LC-MS studies on suitable derivatives confirmed that all the components carry one N-acyl-D-glucosamine and that at least two of them are characterized by N-decanoyl and N-undecanoyl chains on the D-glucosamine unit. The hydrolysis products still possess in vitro and in vivo activity.

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