ANTIBACTERIAL EFFECTS OF CEFROXADINE, CEPHALEXIN AND CEPHRADINE IN A NEW IN VITRO PHARMACOKINETIC MODEL

P. SCHNEIDER; W. TOSCH; M. MAURER; O. ZAK

doi:10.7164/antibiotics.35.843

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

ANTIBACTERIAL EFFECTS OF CEFROXADINE, CEPHALEXIN AND CEPHRADINE IN A NEW IN VITRO PHARMACOKINETIC MODEL

P. SCHNEIDER, W. TOSCH, M. MAURER, O. ZAK

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 7 Pages 843-849

DOI https://doi.org/10.7164/antibiotics.35.843

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Abstract

A pharmacokinetic model has been developed, by means of which all possible time courses of the concentrations of antibiotics in the plasma of treated individuals can be exactly simulated in vitro without diluting the test organism and affecting the growth curves. Equieffective concentrations in the system corresponded to the plasma concentrations in man produced by cefroxadine in a single oral dose of 250 mg and cephalexin and cephradine in a single oral dose of 500 mg.

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