γ-CHLORONORVALINE, A LEUCINE ANALOG FROM STREPTOMYCES

S. NARAYANAN; M. R. S. IYENGAR; P. L. GANJU; S. RENGARAJU; TAKASHI SHOMURA; TAKASHI TSURUOKA; SHIGEHARU INOUYE; TARO NIIDA

doi:10.7164/antibiotics.33.1249

γ-CHLORONORVALINE, A LEUCINE ANALOG FROM STREPTOMYCES

S. NARAYANAN, M. R. S. IYENGAR, P. L. GANJU, S. RENGARAJU, TAKASHI SHOMURA, TAKASHI TSURUOKA, SHIGEHARU INOUYE, TARO NIIDA

Author information

JOURNAL FREE ACCESS

1980 Volume 33 Issue 11 Pages 1249-1255

DOI https://doi.org/10.7164/antibiotics.33.1249

Details

Abstract

γ-Chloronorvaline (AL-719) and γ-hydroxynorvalinelactone (AL-719Y) were isolated from the culture broth of Streptomyces griseosporeus AL-719. Physico-chemical studies led to the structure elucidation of AL-719 and 719Y, with their respective configurations of (2S, 4S) and
(2S, 4R). AL-719 shows antibacterial activity on a synthetic agar, especially against Pseudomonas aeruginosa, which was reversed by L-leucine. The producing strain AL-719 was characterized.

Corresponding author

Register with J-STAGE for free!