Indocarbazostatin and Indocarbazostatin B, Novel Inhibitors of NGF-induced Neuronal Differentiation in PC12 Cells I. Screening, Taxonomy, Fermentation and Biological Activities

NOBUYASU MATSUURA; NORIMASA TAMEHIRO; TSUTOMU ANDOH; AKIRA KAWASHIMA; MAKOTO UBUKATA

doi:10.7164/antibiotics.55.355

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Indocarbazostatin and Indocarbazostatin B, Novel Inhibitors of NGF-induced Neuronal Differentiation in PC12 Cells

I. Screening, Taxonomy, Fermentation and Biological Activities

NOBUYASU MATSUURA, NORIMASA TAMEHIRO, TSUTOMU ANDOH, AKIRA KAWASHIMA, MAKOTO UBUKATA

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JOURNAL FREE ACCESS

2002 Volume 55 Issue 4 Pages 355-362

DOI https://doi.org/10.7164/antibiotics.55.355

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Abstract

During the course of our screening for modulators of signal transduction of mammalian cells, we discovered two novel indolocarbazole antibiotics, indocarbazostatin and indocabazostatin B, from a culture broth of a Streptomyces sp. as inhibitors of NGF-induced neuronal differentiation in rat pheochromocytoma PC12 cells. Indocarbazostatin and indocarbazostatin B inhibited NGF-induced neurite outgrowth from PC12 cells at 6nM and 24nM, respectively, whereas K-252a inhibited at 200nM under our assay conditions.

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