Abstract The progress in medical science has benefited the public. Aside from scientists contribute their wisdom and make efforts to make the progress, in addition, we cannot neglect the contribution made by those who risk their lives to undergo human subject experiments. These people, or so-called human subjects, are so fragile that they lack the ability to protect themselves in the link of human experiment. Currently, the ROC’ regulation system of protecting these human subjects is not sound. It is hoped that the authorities can improve the system to thoughtfully take care of these subjects. Because the experiments, more often than not, are made at the cost of subjects’ health, they cannot be legalized without the consent of the subjects. So “Informed Consent” doctrine is applied and functions as a procedure of securing the subjects’ autonomy and dignity. This system can make experiments legal. It should be noted that this system has been existed in foreign countries in the medical field for years. However, there are still many issues on experiments that left to be discussed. In Taiwan, “Informed Consent” is largely based on the Article 79 of the Medical Law and some administrative regulations such as GCP Guidelines. In applying the principle of “Informed Consent,” the researchers are supposed to disclose and explain to the subject the related information about the experiment. After getting a good understanding of the experiment, the subject can show his/her willingness to participate the experiment. In this case, the subject must have the autonomous ability of giving such consent, that is, the subject must be “competent”. How to define the researcher’s obligation of explanation? How to decide whether the subject is competent? Is it possible for the incompetent person to take part in the experiment? How to make sure that the subject participate in the experiment voluntarily (that is, they are not forced or unduly induced to do so)? For example, are those who consent to take part in placebo-controlled researches volunteers? Do they feel that they have no choice but to do this because of their illness? How to impose proper regulations on this kind of experiments? How to make sure that the aborigines won’t be cheated or unduly induced by the researchers? In addition, can the authorities force certain groups to participate in or not to participate in the experiments because of special “public good” considerations? For instance, can we forbid pregnant women to participate in the experiments in order to protect their fetus? Can we force the prisoners to take part in the experiments because they are get stripped of certain rights? These are the core issues in this paper. In this paper, I use some documents at home and abroad as references. I also examine certain statistical data about the current social reality of Taiwan. It is hoped that this paper can be used as a reference for Taiwan’s medical law making in the near future. The regulations of experiments abroad I referred mainly include the Nuremberg Code, WMA’s Declaration of Helsinki, ICH GCP, Convention on Human Rights and Biomedicine, USA’s Belmont Report and Code of Federal Regulations, and what not. Besides, concerning individual issue, I make comments on related regulations, current local laws, and social reality. In this way, I sincerely advance my suggestions.