In recent years nurses’ retention is the main problem in every medical hospital. Therefore this study is to investigate the leadership effectiveness, role stress, human resourse managerment practice, retaining retention during Feb 10 to March 15 on year 2014. This study use Likert six point scale to interview the nurses’ in south and middle region. This study use SPSS18.0 to execute descriptive statistics, factor analysis, and regression analysis, the total sample is 229. The result is (1) leadership effectiveness and retaining intention is positively influenced, (2) role stress and retaining retention is positively influenced, (3) the moderating effect of HRM practices are significated . The study can be the reference for nurses’ retain retention research.