In 1974, Dr. Amsterdam(the professor of Pennsylvania University) pointed out “periodontal prosthesis” and defined it as “Those restorative prosthetic endeavors that are absolutely essential in the treatment of advanced periodontal disease. whereas specifically it refers to the treatment of the dentition mutilated by the ravages of periodontal disease, in general ,its concepts, principles and techniques may be employed in any restorative or tooth replacement service involving the nature dentition.”The periodontal prosthesis is the “integrated treatment”. In the severe periodontal disease, to achieve the appropriate treatment result and the good prognosis, we need the cooperation of different specialized fields such as operative dentistry, endodontic therapy, periodontal treatment, oral surgery, orthodontics and prosthodontics .The dentist must evaluate the practical need, financial capabilities and personal characteristics of the patient to select the most appropriate treatment plan. In this thesis, the ten cases of the full mouth rehabilitation were presented. These cases applied with the different prosthetic design and the periodontal therapy that included non-surgical ＆ surgical treatment. The surgical treatment included open-flap curettage, furcation involvement therapy, crown lengthening, guided bone regeneration. The orthodontic treatment was used in four cases. The definite prosthesis are fixed or removable partial denture, including conventional fixed prosthesis, implant-supported fixed prosthesis, conventional removable prosthesis, Konuskrone telescopic denture, crown sleeve-coping telescopic denture, overdenture. Again, the patients acquire the stability of the occlusion and the health of the periodontal apparatus by the integrated periodontal-prosthetic treatment and satisfy esthetic appearance.