Backgroud: Currently, numerous epidemiological studies have found associates between periodontal disease and conditions such as diabetes, cardiovascular disease(CVD), and osteoporosis, among others, but there is a lack of consensus on these study conclusions. Furthermore, we investigated the association between bone mineral density(BMD) and periodontal disease(PD) in context of the current periodontal etiology model based on a large community-based PD survey. Material and Methods: In total, 7,298 community residents aged 40-44 years were invited to a community-based survey between 2003 and 2009 using the community periodontal index. Data on quantitative ultrasound(QUS) for measurement of BMD was collected for diagnostic criteria of osteoporosis. Significant factors modifying in the association between BMD and PD were ascertained. We further assessed the association between BMD and PD, within strata of significant effect modifiers, after controlling for other putative factors. A logistic regression model was used to assess the effect of BMD on the risk for PD. Survival model was used to predict a life of PD, showed that the hazard ratio on PD survivability associated each modifying factors. Results: The prevalence of PD was 35% higher in subjects with osteoporosis than in those without. The crude OR for each possible risk factors in association with the risk for PD. Osteoporosis was associated with the risk for PD (OR:1.24,95% CI:1.10-1.40). Other significant factors included age, obesity, type Ⅱ diabetes mellitus, smoking, male, metabolic syndrome components. After controlling for significant factors, the worst BMD group was positively associated with the risk for PD(adjusted odds ratio=1.36, 95% CI：1.19- 1.57).The significant effect of BMD was not found in Cox regression model. Conclusion: The association between osteoporosis and the risk for PD among young adults was demonstrated. Intervention program for prevention of PD and osteoporosis may be considered starting from the young adults.