This article describes the emergency nursing experience of a patient with hyperbaric oxygen therapy test leading to multiple barotraumas, including diffuse pneumocephalus, spontaneous pneumothorax and seizures. The emergency treatment period was from 09：47 to 11：30 of December 9, 2016. According to physiological, psychological, social, and spiritual assessments, the author collected data through physical assessment, conversations, and observation. The major health problems included ineffective tissue perfusion/brain, impaired gas exchange, impaired physical mobility, anxiety, and acute pain. The author took care of these barotraumatic complications via nursing care including monitoring the patient's consciousness, checking the patient's pupil size reflex, maintaining the patient's head position and raising the bed, assessing limbs muscle power, listening to the patient and establishing a good relationship during the nursing process, reducing anxiety, and using the ISBAR principles to pass messages to the intensive care unit nurse. Combining interprofessional practices such as hyperbaric oxygen, internal medicine medical and thoracic surgery allowed the case to be involved in decision-making, prompting individual endeavor to develop positive attitudes towards the disease. It is expected that by sharing this one-time nursing experience, it will provide information to clinical nurses in different fields in reserving multifaceted and substantial professional care, not only to promote the ability to enhance clinical care of recovering patients but to promote health in a timely fashion.