The objective of this study is to investigate the economic, life, and environmental influences at the Park’s neighbor townships such as Shinshi, Shanhua and Anding after the operation of the Tainan Science Park in 1998. Questionnaire designed and setup based on literature review and on-site investigation has been distributed and the interview has been carried out to the interviewees intently and randomly. A total of 328 effective copies of questionnaires have been recovered. Through the t-test comparison the environmental issue has the highest agreement degree, followed by economic and life issues. Highest agreement degree has been found in the green fence establishment among 5 questions asked in the environment issue. Tall trees cultivated in double layer for green fence within the Park’s limit can be used to reduce noise and air pollutions. The next is the shade trees on the side walk. The native tree such as Taiwan flame gold tree (Koelreuteria henryi Dummer) should be selected to increase the effects of greening, beauty and shading in the Park region. Among 5 questions within the economic issue, the feed-back compensation to subsidy the neighbor township gains the highest agreement degree. Firstly, the calculation of the amount of feed-back compensation must be clear to ensure the fair distribution and effective uses. Secondly, local integrated development for public construction is also concerned. For example, the flooding problem at Hsinshi Township has been solved through the well-planned drainage system around the Park. However, solving and improving the flooding situation at some places are still needed to be covered by the well-planned regional drainage system. Five questions including Hsinshi Intersection of High Way 8 and roads to the Hsinshi Township gain the highest agreement degree among 12 questions asked in the life issue. Traffic jam caused by heavy vehicle flow at the intersection and near-by roads can be solved by the setup of suitable traffic light system to guide the right driving direction of vehicles. The next high agreement degree is the house rental and purchasing at the neighbor townships. People will be attracted to buy or rent house at regions where have well-planned urban plan and good life functions. Summarized from the analytical results of environmental, economical, and life issues, the measures of improvements have been proposed to increase the welfare of residents, sustain the good living environment and the utilization of resources for mutual gloried development and sustainable co-existence between the Tainan Science Park and its neighbor townships.