Vaibhavi Vijay Kshatriya*, Manoj Ramesh Kumbhare, Shraddha Vikas Jadhav, Prajakta  Jaywant  Thorat, Rushikesh Gajanan Bhambarge.

Department of Pharmaceutical Chemistry, S.M.B.T. College of Pharmacy, Affiliated to Savitribai Phule Pune University, Dhamangaon, Nashik, M.S. India-422403.
* Address    for  Correspondence:

Department of Pharmaceutical Chemistry, S.M.B.T. College of Pharmacy, Affiliated to Savitribai Phule Pune University, Nandi Hills,Dhamangaon,Tal-Igatpuri, Dist-Nashik, M.S., India-422403
Email: vaibhavikshatriya5086@gmail.com  Contactno.+91-9762755260

Abstract

Silver nanoclusters (AgNCs) have emerged as versatile nanomaterials with immense potential in theranostic applications, combining therapeutic and diagnostic functions in a single platform. This review provides a comprehensive overview of recent advancements in the synthesis, characterization, and utilization of AgNCs for theranostics. The synthesis of AgNCs has witnessed significant progress, with numerous strategies such as chemical reduction, green synthesis, and templated approaches being employed to control size, shape, and stability. Their unique optical properties, including strong fluorescence and surface-enhanced Raman scattering (SERS) signals, make AgNCs ideal candidates for bioimaging and diagnostic purposes. Additionally, the surface chemistry of AgNCs allows for facile functionalization with targeting ligands and therapeutic agents, enhancing their specificity and efficacy. In the realm of diagnostics, AgNCs have been employed for various imaging modalities, including fluorescence imaging, photoacoustic imaging, and SERS-based sensing. Their excellent photostability and biocompatibility make them suitable for in vitro and in vivo imaging applications, enabling the real-time monitoring of disease progression and treatment response.

Keywords  Silver nanoclusters, theranostics, bioimaging, biosensors, targeted therapy, personalized medicine, nanomedicine

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