The teaching site of insect curriculum is often limited by weather, environment, and resources. It is hard cultivate the scientific process skills of primary school students. This study developed the ＂Insects Playing Board Games＂ as media, allowing students to cultivate scientific process skills and enhance insect cognitive comprehension through playing. We used ＂Insect Science Process Test, ISPT,＂ ＂Insect Cognitive Comprehension Test, ICCT,＂ and an interview outline as research tools to evaluate the learning effect of our mixed-method research. The result showed that: 1. the experimental group students (playing the ＂Insects Playing Board Games＂) showed better learning effect on the ＂scientific process skills＂ and ＂insect cognitive comprehension＂ than the control group, reaching significant differences; 2. the ISPT and ICCT effect sizes (ES) of the experimental group students were higher than the control group in the total, as well as in the high-, medium- and low-achiever groups, reaching medium to high degree of effect size; 3. interviewed students of the experimental group thought that their capabilities of science process skills did enhance with the 20 kinds of insect cards and the ＂teaching manual.＂