Open Access, Peer-reviewed
pISSN 2288-6478
eISSN 2288-6761
    J Korean Soc Menopause. 2013 Aug;19(2):87-92. Korean.
    Published online Aug 27, 2013.
    https://doi.org/10.6118/jksm.2013.19.2.87
    Copyright © 2013 by The Korean Society of Menopause
    Original Article

    A Clinical Analysis of Patients with Premature Ovarian Failure: Compliance with Hormonal Treatment

    Hee Suk Lee, M.D.,1 Ji Hoon Ok, M.D.,1 Joo Myung Kim, M.D., Ph.D.,2 and Yeon Jean Cho, M.D., Ph.D.1
      • 1Department of Obstetrics and Gynecology, Dong-A University Medical Center, Dong-A University, College of Medicine, Busan, Korea.
      • 2Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
    • Address for Correspondence: Yeon Jean Cho, Department of Obstetrics and Gynecology, Dong-A University School of Medicine, Dongdaeshin-dong 3 ga-1, Seo-gu, Busan 602-715, Korea. Tel: +82-51-240-5090, Fax: +82-51-244-9553, Email: jeanjane@naver.com
    Received June 09, 2013; Revised July 10, 2013; Accepted July 23, 2013.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

    Abstract

    Objectives

    To analyze the clinical features of premature ovarian failure (POF) and patients' compliance with hormonal treatment.

    Methods

    A retrospective analysis of 126 patients diagnosed with POF was selected between January 2004 and December 2007. The clinical, etiologic features and treatment compliance were evaluated.

    Results

    The mean age of diagnosis was 33.2 ± 5.2 years. The mean value of follicle stimulating hormone was 78.8 ± 28.8 IU/L. The most common symptom was amenorrhea or oligomenorrhea (54%). Eighty-eight patients were married and 22 of them visited our clinic due to infertility. The most common etiology was unknown (54.8%) and the second most common cause was iatrogenic (29.4%). Only 61 patients underwent hormonal treatment (48.4%). The remaining 11 patients did not undergo hormonal treatment due to other medical conditions such as breast cancer or liver disease; however, they were followed-up regularly (8.7%). Among the treatment group, only 37 patients were followed-up over a period of 12 months (60.7%).

    Conclusion

    About half of the women diagnosed with POF did not accept their own problems and therefore delayed essential treatment. Clinicians should educate the importance of early treatment for preventing degenerative changes.

    Keywords
    Compliance; Hormone replacement therpay; Premature ovarian failure; Primary ovarian insufficiency

    Tables

    Table 1
    Patients' characteristics (n = 126)

    Table 2
    Etiology of premature ovarian failure

    Table 3
    Patients' compliance with hormonal treatment

    Table 4
    Age group and hormonal treatment

    Table 5
    Etiology and hormonal treatment

    Notes

    This work is supported by the Dong-A University research fund.

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    MeSH Terms
    Amenorrhea
    Breast Neoplasms
    Compliance
    Female
    Follicle Stimulating Hormone
    Humans
    Infertility
    Liver
    Oligomenorrhea
    Primary Ovarian Insufficiency
    Retrospective Studies
    Metrics
    Share
    Tables
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