Additional file 1: of Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

Figure S1. Schematic diagram of the chemical enrichment process of AP-sites using an aldehyde reactive probe. Figure S2. Quality control measures for successful treatment and pulldown specificity. Figure S3. Sequencing statistics for AP-seq. Figure S4. Additional data for damage distribution including all treatment conditions. Figure S5. Additional data on GC content, transcription, or accessibility dependence. Figure S6. Reanalysis of the analysis by Ding et al. Figure S7. SNVs from POLE proofreading-deficient cancers follow distinct patterns. Figure S8. SNVs from POLE proofreading-deficient cancers spare out high GC content DNA, irrespective of replication timing. Figure S9. Trinucleotide distribution in high GC content DNA. (PDF 9209 kb)