Additional file 1 of The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam

Additional file 1: Supplementary Table 1. Probability of stopping recruitment into a group. Supplementary Table 2. Predicted recruitment schedule. Supplementary Table 3. Sensitivity analysis of the timing of interim analyses comparing recruiting over 24 months to recruiting over 18 or 30 months. Supplementary Table 4. Sensitivity analysis of the timing of interim analyses altering the lower limit of the uniform distribution over which cure rates of genuinely inferior arms are assumed to be distributed. Supplementary Table 5. Sensitivity analysis comparing the use of a posterior probability-based rule to a predictive probability-based rule with a beta (4.5, 0.5) prior. Supplementary Figure 1. Cumulative probability of stopping interferon groups for different interim analysis schedules. Supplementary methods.