Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis
Figure 7
MYC-induced Proliferation and Tumorigenesis in Hepatotoxin-Treated Livers is Associated with Increased Cyclin B1 Expression.
Real-time quantitative PCR of: (A) human c-MYC mRNA, (B) mouse Ornithine Decarboxylase (ODC) mRNA, (C) mouse Nucleolin mRNA, and (D) mouse Cyclin B1 mRNA. Statistical significance was measured using a Mann Whitney test (* P<0.05, ** P<0.05, *** P<0.05). Gray bar graphs represent normal adult livers in which MYC was overexpressed for the times indicated. White bar graphs represent normal neonatal livers in which MYC was overexpressed. Red bar graphs represent DDC-treated livers in which MYC was either overexpressed (MYC ON/DDC) or kept inactive (MYC OFF/DDC). Blue bar graphs represent CCl4-treated livers in which MYC was either overexpressed (MYC ON/ CCl4) or kept inactive (MYC OFF/ CCl4). mRNA was quantitated from four different liver samples per time-point.