Abstract: Because of structural features, creeping diseases can be easily produced in curved bridges. Creeping diseases will reduce driving comfort and endanger structural safety. The existing research showed that the factors of creeping phenomenon had been analyzed. Taking an overpass bridge as an example, the features of radial displacement were analyzed under the effects such as dead loads, live loads, concrete shrinkage and creep, temperature, prestress, and so on. The influences of supporting form, bearing eccentricity, and bearing form on creeping, were also discussed. The study shows that supporting form and bearing eccentricity optimization method can be used when small traffic and curvature radius were applied in curved bridges. The bearing form optimization is applicable when heavy traffic, large curvature radius and torsional stiffnesses are shown in the curved bridges. When doing optimization design for a new curved bridge, the above three method and their mixed forms can all be applied for preventing creeping diseases.