Evidence-based Pharmaceutical Evaluation of Clinical Antitumor Efficacies of 4 Kinds of Common TCM InjectionsChinese Full Text
CAO Li-hui;CAI Shao-hui;XU Jun;HUANG Si-chao;ZHONG Jin-song;College of Pharmacy,Jinan University;College of Medicine,Jinan University;Dept.of Pharmacy,Zhuhai Municipal People’s Hospital;
Abstract: OBJECTIVE:To evaluate the effectiveness of Kang’ai injection,Lentinan injection,Shenqi fuzheng injection and Compound kushen injection combined with chemotherapy,radiotherapy or operation for non-small cell lung cancer（NSCLC）,gastric cancer and intestinal cancer.METHODS:Retrieved from CNKI,CBM and VIP database from Jan.2006 to Dec.2012,literatures about the effectiveness of 4 kinds of TCM injection were included,and the quality of included literatures was evaluated by cancer type.Then frequency analysis and chi-square analysis were applied to analyze each therapeutic index including clinical efficacy,quality of life,gastrointestinal tract reaction and bone marrow suppression.RESULTS:132 literatures were enrolled in this study.The frequency analysis（literatures with statistical significance between 2 groups/total amounts of literatures）showed that quality of life（89/132）,clinical efficacy（37/132）,bone marrow suppression（96/132）and gastrointestinal tract reaction（81/132）were the major therapeutic indexes.Furthermore,the chi-square analysis indicated:① in NSCLC（84 literatures）,the main 4 therapeutic indexes were improved significantly when chemotherapy,radiotherapy or operation combined with Kang’ai injection,Lentinan injection,Shenqi fuzheng injection or Compound kushen injection（P＜0.05）;② in gastric cancer（24 literatures）,chemotherapy,radiotherapy or operation combined with Kang’ai injection and Lentinan injection would improve the quality of life,reduce gastrointestinal tract reaction and bone marrow suppression significantly（P＜0.05）;③ in intestinal cancer（24 literatures）,chemotherapy,radiotherapy or operation combined with Kang’ai injection,Lentinan injection and Shenqi fuzheng injection could improve quality of life and reduce gastrointestinal tract reaction significantly（P＜0.05）;and chemotherapy,radiotherapy or operation combined with Compound kushen injection may enhance clinical efficacy and the quality of life,meanwhile lessen bone marrow suppression（P＜0.05）.CONCLUSIONS:For therapies of various tumors,Kang’ai injection,Lentinan injection,Shenqi fuzheng injection and Compound kushen injection display different significant efficacies.The systematic review provides the corresponding evidence-based pharmaceutical information for the clinical antitumor therapeutics with the 4 kinds of TCM injections.
Keywords：
Anti-cancer; TCM injection; Therapeutic efficacy; Adverse drug reaction; Systematic review; Evidence-based pharma ceutical;
- Series：
(E) Medicine ＆ Public Health
- Subject：
Traditional Chinese Medicinal Herbs
- Classification Code：
R285
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