1999 Volume 90 Issue 8 Pages 731-740
17 cases of patients with diabetes mellitus who had urinary frequency symptom for which anticholinergic agents proved ineffective were given Sarpogrelate Hydrochloride (Anplag®), a selective 5-HT 2 receptor antagonist.
Efficacy was judged using IPSS and QOL scores after 2 weeks medications, these showed that all cases had improved their urinary frequency during the days as well as the night. This was especially true for the QOL score.
One time urinary volume markedly increased, but there was no statistical significance after medication in maximum flow rate and residual urine. At the same time, a separate group of 14 mainly BPH cases did not improve entirely. It is believed that reaction in the detrusor muscle with hyperreflexia of diabetes mellitus patients can reach 5-HT, and its reaction is belived to reach via the 5-HT 2 receptor.
This paper is a first clinical report of making use of 5-HT 2 antagonist as hyperactive detrusor on diabetes mellitus patients.
