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2015, vol. 44, br. 2, str. 35-39
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Nezeljena dejstva salicilata (ACK), kortikosteroida i imunomodulatora na sluznicu gastroduodenuma - lekovima ordiniranih u terapiji reumatoidnog artritisa
Iside effects of salicylates (ACK), corticosteroids and imunomodulators on the gastroduodenal mucosa - medication used in rheumatoid arthritis treatment
aUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Medicinski fakultet, Katedra za Internu medicinu, Srbija bSpecijalisticka ordinacija, Gornje Ljubinje cUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Medicinski fakultet, Srbija
e-adresa: cukicapop@yahoo.com
Ključne reči: Reumatoidni arthritis ACK-a; salicilati; kortikosteroidi imunomodulatori; patološke promene nasluznici gastroduodenuma
Sažetak
Cilj rada je da utvrdi patoloske ulcero-erozivne promene na sluznici gastroduodenuma (erozije,ulceracije, ulkusi, komplikacije ulkusa,subepitelna krvarenja i dr) nastalih kao posledica stetnog dejstva salicilata /ACK/ kotikosteroida, imunoodulatora koji su ordinirani u terapiji Reumatoidnog artritisa (RA). Ispitivanje je vrseno na 50 bolesnika sa dijagnostikovanim RA koji su bili na kontinuiranoj dvogodisnjoj terapiji. Kod ispitanika je radjena gastroskopija a patoloske makromorfoloske promene nastale na sluznici gastroduodenuma kao posledica nezeljenog dejstva ordiniranih lekova verifikovane. Posle dvogodisnje kontrolisane terapije preparatima ACK , kortikosteroida, imunomodulatora na sluznici gastroduodenuma erozije su nadjene u 81.5% ispitanika, ulkus zeluca u 33%, duodenalni ulkus kod 18.5% bolesnika a krvarenje u 44,4%.
Abstract
The aim is to determine pathological -ulcero-erosive changes in the gastroduodenal mucosa (erosions, ulcers, ulcers, ulcer complications, subepithelial hemorrhage, etc.) resulting from the adverse effects of salicylates /ACK/ corticosteroid, imunoodulatora which was prescribed in the treatment of rheumatoid arthritis (RA). The test was performed on 50 patients diagnosed with RA who were on the two-year continuous therapy. When respondents were done gastroscopy and pathological macroscopic changes resulting from the gastroduodenal mucosa as a result of adverse effects of administered drugs verified. After two years of preparations ACK controlled therapy, corticosteroids, imunomodula- sector on mucosa gastroduodenal erosions were found in 81.5% of patients, gastric ulcer in 33%, duodenal ulcer with 18.5% of patients and bleeding in 44.4%.
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Reference
|
|
  
|
Berger, J.S., Brown, D.L., Becker, R.C. (2008) Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis. American Journal of Medicine, 121(1): 43-49
|
|
|
Chey, W.D., Scheiman, J.M. (2003) Peptic ulcers disease. u: Fredman L.S., Mcquaid Grendel J.H. [ur.] Current diagnosis tretman in gastroenterology, New York: McGraw-Hill Medical, 2nd ed., 323-54
|
|
|
Douthwaite, A.H., Lintott, G.A.M. (1938) Gastroscopic observation of the effect of aspirin and certain other substances on the stomach. Lancet, 232(6013): 1222-1225
|
|
|
Gimbel, J.S., Brugger, A., Zhao, W., Verburg, K.M., Geis, G.S. (2001) Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults. Clinical therapeutics / Clin Ther, 23(2): 228-41
|
|
|
Green, Ga. (2000) Understanding NSAID from aspirin to Cox -2. clinical cornerstone, 3, (5), 50-60, doi 10.1016/S1098-3597(01)90069-9
|
|
|
Hawkey, C.J., Karrasch, J.A., Szczepañski, L., Walker, D.G., Barkun, A., Swannell, A.J., Yeomans, N.D. (1998) Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. New England Journal of Medicine, 338(11): 727-34
|
|
|
Huscher, D., Thiele, K., Gromnica-Ihle, E., et al. (2009) Dose-related pattens of glukocoticoid -induced side effects. An Rheum Diss, 68, 1119
|
|
|
Laine, L., Maller, E.S., Yu, C., Quan, H., Simon, T. (2004) Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: A double-blind trial. Gastroenterology, 127(2): 395-402
|
|
|
Ng, F., Wong, S., Lam, K., i dr. (2009) Famotidine is inferior to pantoprazol in preventig recurrence of aspirin-related peptic ulcers or erosions. Gastroentrrology, Jan, 138, (1), 82-8, Epub 2009, Nov 11
|
|
|
Rodríguez, L.A.G., Hernández-Díaz, S. (2001) Relative Risk of Upper Gastrointestinal Complications among Users of Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs. Epidemiology, 12(5): 570-576
|
|
|
Roth, S. (2012) Coming to terms with nonsteroidal anti inflammatory drug gasropaty. Drugs, 873-879
|
|
6
|
Vane, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol, 231(25): 232-5
|
|
|
|
|