Restless legs syndrome in patients on hemodialysis: Frequency, severity and risk factors

Sladojević, Nikola; Knežević, Marinela; Jović, Jelena; Đorđević, Vidojko

doi:10.5937/mckg46-2330

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Medicinski časopis

2012, vol. 46, br. 3, str. 138-144

Sindrom nemirnih nogu kod pacijenata na hemodijalizi - učestalost, težina i faktori rizika

Sladojević Nikola^a, Knežević Marinela^b, Jović Jelena^b, Đorđević Vidojko^c

^aInstitut za patologiju, Univerzitet u Mičigenu, En Arbor, Mičigen, SAD + Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija
^bUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija
^cKlinički centar Niš, Klinika za nefrologiju, Srbija

e-adresa: drvidza@gmail.com

Ključne reči: sindrom nemirnih nogu; bubrežna dijaliza; faktori rizika

Sažetak

Cilj. Sindrom nemirnih nogu je neurološki poremećaj koji posebno pogađa pacijente na hemodijalizi. Cilj studije je da prikaže učestalost i težinu sindroma nemirnih nogu u populaciji hemodijaliznih pacijenata i razmotri moguću povezanost s određenim faktorima analizirajući razlike između pacijenata s dijagnozom sindroma i bez dijagnoze u sociodemografskim karakteristikama, prisustvu i težini komorbidnih stanja, biohemijskim parametrima i vrsti hemodijalizne tehnike. Metode. Studijom preseka obuhvaćeno je 96 pacijenata. Dijagnoza sindroma nemirnih nogu postavljena je na osnovu dijagnostičkih kriterijuma Međunarodne studijske grupe za sindrom nemirnih nogu. Za procenu težine korišćen je upitnik Restless Legs Syndrome Rating Scale. Rezultati. Sindrom nemirnih nogu bio je prisutan kod 39,6% ispitanika. Većina pacijenata imala je umerene (36,8%) ili jako izražene simptome (50%). Nije bilo statistički značajne razlike u sociodemografskim i biohemijskim karakteristikama i vrsti dijalize između pacijenata sa sindromom nemirnih nogu i onih bez sindroma. Kada je reč o udruženim bolestima nađeno je da pacijenti sa sindromom nemirnih nogu imaju statistički značajno veću učestalost ishemijske bolesti srca i depresivnosti, dok u ukupnom indeksu težine pratećih oboljenja nema razlike. Težina depresivnosti i nesanice su izraženiji kod pacijenata sa sindromom nemirnih nogu. Zaključak. Naša studija je potvrdila visoku učestalost sindroma kod pacijenata na hemodijalizi i pokazala da čak dve trećine pacijenata ima jake do veoma jake simptome. Posebnu pažnju potrebno je usmeriti ka uticaju komorbiditeta na sindrom nemirnih nogu u ovoj grupi pacijenata, posebno onih iz grupe psihijatrijskih bolesti.

Abstract

Objective. Restless legs syndrome is a neurologic disorder which especially affects patients on hemodialysis. The aim of our study was to estimate the frequency and severity of restless legs syndrome in hemodialysis patients' population and explore possible connection with some factors by analyzing differences in patients' sociodemographic characteristics, existence and severity of coexistent diseases, biochemical parameters and dialysis type between the patients with and without this syndrome. Methods. 96 subjects were included in our cross sectional study. The diagnosis of restless legs syndrome was made by using criteria of International Restless Legs Study Group. Severity of the syndrome was evaluated through the use of Restless Legs Syndrome Rating Scale questionnaire. Results. Restless legs syndrome was found in 39.6% of subjects. The most of patients had moderate (36.8%) or severe symptoms (50%). There was no statistically significant difference between the patients with and without restless legs syndrome regarding sociodemographic and biochemical characteristics and dialysis type. In terms of coexistent disease, it was found that patients with restless legs syndrome had a significantly greater frequency of ischemic heart disease and depression compared to the patients without the syndrome. There was no difference in index of coexistent disease. Severity of depression and insomnia was higher in patients with restless legs syndrome. Conclusion. This study confirmed that restless legs syndrome is very frequent in hemodialysis patients and indicated that even two-third of patients had severe to very severe symptoms. For future research, it is necessary to direct attention to influence of comorbidity in hemodialysis patient on restless legs syndrome, especially on influence of psychiatric disorders.

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O članku

jezik rada: srpski
vrsta rada: stručni članak
DOI: 10.5937/mckg46-2330
objavljen u SCIndeksu: 03.12.2012.

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