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Interakcija između klopidogrela i statina - karika koja nedostaje
aUniverzitet u Beogradu, Medicinski fakultet, Institut za farmakologiju, kliničku farmakologiju i toksikologiju, Srbija + Univerzitet u Beogradu, Medicinski fakultet, KBC 'Bežanijska kosa', Srbija
bHigh Medical School Milutin Milanković, Belgrade
cVojnomedicinska akademija, Centar hitne pomoći, Beograd, Srbija
dUniverzitet u Beogradu, Medicinski fakultet, Institut za farmakologiju, kliničku farmakologiju i toksikologiju, Srbija
eUniverzitet u Beogradu, Medicinski fakultet, Srbija

e-adresazoran.todorovic@mfub.bg.ac.rs
Projekat:
Projekat Ministarstva nauke Republike Srbije, br. 145046
Ministry of Science of Montenegro, No. 01-1370
Ministry of Science of Montenegro 01­907/2

Ključne reči: klopidogrel; resistancija; statini; interakcija
Sažetak
Uvod: Primena klopidogrela je povezana sa velikim varijabilnošću u odgovoru na ovaj lek, pri čemu rezultati velikog broja studija ukazuju da čak jedan od tri pacijenta može biti u kategoriji onih koji ne odgovaraju na lek. Tema: Među brojnim uzrocima koji modifikuju farmakodinamski efekat klopidogrela, posebna pažnja se posvećuje mogućoj klopidogrel - statin interakciji. Brojne studije su bile fokusirane na ovaj problem, ali se ipak čini da još uvek nedostaje pravi odgovor. Zaključak: U ovom radu iznete su neke od najvažnijih činjenica u vezi sa istovremenom upotrebom klopidogrela i statina, kao i specifična pitanja koja treba rešiti radi bezbednog lečenja pacijenata.
Reference
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/hpimj1602395T
objavljen u SCIndeksu: 09.09.2016.
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