African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12484

Full Length Research Paper

Volatile constituents and behavioral change induced by Cymbopogon winterianus leaf essential oil in rodents

Bárbara L. S. Leite1, Thais T. Souza1, Angelo R. Antoniolli1, Adriana G. Guimarães1, Rosana S. Siqueira1, Jullyana S. S. Quintans1, Leonardo R. Bonjardim1, Péricles B. Alves2, Arie F. Blank3, Marco Antonio Botelho4, Jackson R. G. S. Almeida5, Julianeli T. Lima5, Adriano A. S. Araújo1 and Lucindo J. Quintans-Júnior1*
1Departamento de Fisiologia, Universidade Federal de Sergipe. Campus Universitário “Prof. Aloísio de Campos” CEP: 49100-000, São Cristóvão, SE, Brazil. 2Departamento de Química, Universidade Federal de Sergipe. Campus Universitário “Prof. Aloísio de Campos” CEP: 49100-000, São Cristóvão, SE, Brazil. 3Departamento de Agronomia, Universidade Federal de Sergipe. Campus Universitário “Prof. Aloísio de Campos” CEP: 49100-000, São Cristóvão, SE, Brazil. 4nstituto Federal de Educação Ciência e Tecnologia do Ceará, Departamento de Pesquisa. Laboratório de Biotecnologia. CEP: 62700-000, Canindé, CE, Brazil. 5Colegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco. CEP 56.306-410, Petrolina, PE, Brazil.
Email: [email protected], [email protected].

  •  Accepted: 09 June 2011
  •  Published: 08 August 2011

Abstract

Cymbopogon winterianus Jowitt (‘Java citronella’) is an important essential oil yielding aromatic grass cultivated in India and Brazil and its volatile essential oils extracted from its leaves are used in perfumery, cosmetics, pharmaceuticals and flavoring industries. However, there is no report on any psychopharmacological study of C. winterianus leaf essential oil (LEO) available to date. In this study, the pharmacological effects of the LEO were investigated in animal models and its phytochemical analyses. GC-MS analysis showed a mixture of monoterpenes, as citronellal (36.19%), geraniol (32.82%) and citronellol (11.37%). LEO exhibited an inhibitory effect on the locomotor activity of mice, an antinociceptive effect by increasing the reaction time in the writhing and capsaicin tests. All doses induced a significant increase in the sleeping time of animals not having modified however, the latency. The LEO did not alter the remaining time of the animals on the rota-rod apparatus. These results suggest a possible central effect.

 

Key words: Cymbopogon winterianus, essential oil, CNS, behavioral effects, analgesic.

Abbreviation

LEO, Leaf essential oil; EO, essential oil.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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