Expressions of c-Cbl,Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance
Qian Dong , Yun-Peng Liu, Xiu-Juan Qu, Ke-Zuo Hou, Lin-Lin Li
Department of Medical Oncology, The First Affiliated Hospital,China Medical University, Shenyang, 110001, Liaoning, P. R. China. cmuliuyunpeng@yahoo.cn
[Abstract] Background and Objective: c-Cbl and Cbl-b are two major members of the Casitas B-lineage lymphoma (Cbl) family, which play important roles in down-regulation of epidermal growth factor receptor (EGFR) by acting as E3 ubiquitin ligases and multi-adaptor proteins. This study was to investigate the expressions of c-Cbl, Cbl-b, and EGFR in gastric carcinoma and their clinical significance. Methods: The expressions of c-Cbl, Cbl-b, and EGFR were detected by immunohistochemistry using tissue microarrays consisting of 124 specimens of gastric carcinoma and 16 specimens of normal gastric mucosa. The relationship between the expressions of c-Cbl,Cbl-b, and EGFR and clinicopathologic factors of gastric carcinoma were analyzed statistically. Results: The positive rates of c-Cbl, Cbl-b, and EGFR were higher in the gastric carcinoma group than in the normal group (71.0% vs.18.0%, P<0.01；82.3% vs. 25.0%, P<0.01； 56.5% vs. 12.5%, P<0.01, respectively). The expression of c-Cbl was positively correlated with depth of invasion (r=0.219,P=0.015) and TNM staging (r=0.266,P=0.003). The expression of Cbl-b was positively correlated with lymph node metastasis (r=0.190, P=0.034) and TNM staging (r=0.298, P=0.001). The expression of EGFR was positively correlated with depth of invasion (r=0.286, P=0.001) and TNM staging (r=0.362, P=0.000). The expression of c-Cbl or Cbl-b was positively correlated with EGFR (r=0.241, P=0.007； r=0.183, P=0.042, respectively). Synchronously strong-positive expressions of c-Cbl, Cbl-b, and EGFR were observed in 27 specimens of gastric carcinoma, most of which were at advanced stage. Conclusion: The overexpressions of c-Cbl, Cbl-b, and EGFR are closely related to the invasion and progression of gastric carcinoma. c-Cbl and Cbl-b may serve as novel molecular markers for gastric carcinoma.
Chinese Journal of Cancer 2010, Volume: 29, Issue 1, Page: 56-
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