Dietary Supplementation with Sodium Butyrate Reduces High-sucrose Diet-induced Hepatic Accumulation of Triacylglycerols and Expression of Fatty Acid Synthesis Enzymes in Rats

Yutaka Hattori; Sayo Tsutsui; Chihiro Yamada; Yota Kobayashi; Tomoyuki Nakagawa; Masaya Shimada

doi:10.5650/jos.ess22112

Nutrition and Health Function

Dietary Supplementation with Sodium Butyrate Reduces High-sucrose Diet-induced Hepatic Accumulation of Triacylglycerols and Expression of Fatty Acid Synthesis Enzymes in Rats

Yutaka Hattori, Sayo Tsutsui, Chihiro Yamada, Yota Kobayashi, Tomoyuki Nakagawa, Masaya Shimada

Author information

Yutaka Hattori
Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University
Sayo Tsutsui
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
Chihiro Yamada
Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University
Yota Kobayashi
Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University
Tomoyuki Nakagawa
Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
Masaya Shimada
Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University

Keywords: fatty acid synthase, malic enzyme, nonalcoholic fatty liver disease

JOURNAL OPEN ACCESS

2022 Volume 71 Issue 8 Pages 1189-1193

DOI https://doi.org/10.5650/jos.ess22112

Details

Abstract

We investigated the effects of dietary supplementation with sodium butyrate (NaB) on the lipid levels, gene expression, and proteins related to lipid metabolism in nonalcoholic fatty liver disease (NAFLD) rat models fed a high-sucrose diet for 3 weeks. Supplementation with 1% and 3% NaB reduced high-sucrose-induced hepatic triacylglycerol levels and expression of genes and proteins related to fatty acid synthesis, such as fatty acid synthase and malic enzyme, in a dose-dependent manner. NaB supplementation did not affect hepatic cholesterol levels or expression of genes related to β-oxidation. NaB may prevent high-sucrose-induced NAFLD by repressing the fatty acid synthesis pathway.

graphical abstract Fullsize Image

Corresponding author

Register with J-STAGE for free!