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Increased risk of endometriosis in patients with endometritis — a nationwide cohort study involving 84,150 individuals
Affiliations- Department of Obstetrics and Gynecology, Women and Children’s Health, Royal North Shore Hospital, Sydney, NSW, Australia
- School of Medicine, China Medical University, Taichung, Taiwan
- Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
- School of Chinese Medicine, China Medical University, Taichung, Taiwan
- Department of Biotechnology, Asia University, Taichung, Taiwan
open access
Abstract
Objectives: To evaluate the incidence of endometriosis among endometritis patients and its association with confounding
comorbidities.
Material and methods: A population-based, retrospective cohort study of women aged between 20 to 55 years, who were
newly diagnosed with endometritis between 2000 to 2013. A total of 16,830 endometritis patients and 67,230 non-endometritis
individuals were enrolled by accessing data from the National Health Insurance Research Database of Taiwan.
The comorbidities accessed were uterine leiomyoma, rheumatoid arthritis, ovarian cancer, infertility and allergic diseases.
Results: The mean follow-up period was 9.15 years for the non-endometritis cohort and 9.13 years for the endometritis
cohort. There were significantly higher percentages of uterine leiomyoma, rheumatoid arthritis, infertility, ovarian cancer
and allergic diseases in the endometritis cohort than in the non-endometritis cohort. Patients with endometritis had
a 1.5-fold increased risk of their condition advancing to endometriosis (HR 1.58, 95% CI 1.48–1.68).
Conclusions: Our results suggest that patients with endometritis exhibited a positive correlation in developing endometriosis.
Abstract
Objectives: To evaluate the incidence of endometriosis among endometritis patients and its association with confounding
comorbidities.
Material and methods: A population-based, retrospective cohort study of women aged between 20 to 55 years, who were
newly diagnosed with endometritis between 2000 to 2013. A total of 16,830 endometritis patients and 67,230 non-endometritis
individuals were enrolled by accessing data from the National Health Insurance Research Database of Taiwan.
The comorbidities accessed were uterine leiomyoma, rheumatoid arthritis, ovarian cancer, infertility and allergic diseases.
Results: The mean follow-up period was 9.15 years for the non-endometritis cohort and 9.13 years for the endometritis
cohort. There were significantly higher percentages of uterine leiomyoma, rheumatoid arthritis, infertility, ovarian cancer
and allergic diseases in the endometritis cohort than in the non-endometritis cohort. Patients with endometritis had
a 1.5-fold increased risk of their condition advancing to endometriosis (HR 1.58, 95% CI 1.48–1.68).
Conclusions: Our results suggest that patients with endometritis exhibited a positive correlation in developing endometriosis.
Keywords
endometritis; inflammation; microbial infection; endometriosis
About this articleTitle
Increased risk of endometriosis in patients with endometritis — a nationwide cohort study involving 84,150 individuals
Journal
Issue
Article type
Research paper
Pages
193-200
Published online
2020-04-29
Page views
1504
Article views/downloads
1183
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(4):193-200.
Keywords
endometritis
inflammation
microbial infection
endometriosis
Authors
Kent Yu-Hsien Lin
Cherry Yin-Yi Chang
Wu-Chou Lin
Lei Wan
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